Characterization of the SARS-CoV-2 coronavirus X4-like accessory protein
| Autor: | Nkwachukwu Oziamara Okoro, Olanrewaju Ayodeji Durojaye, Arome Solomon Odiba |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Medicine (General) Sequence analysis viruses Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Computational biology QH426-470 Biology medicine.disease_cause Virus Viral Structure 03 medical and health sciences R5-920 0302 clinical medicine X4 protein Genetics medicine Genetics (clinical) Coronavirus Phylogenetic tree SARS-CoV-2 Research COVID-19 Model protein 030104 developmental biology 030217 neurology & neurosurgery Ramachandran plot |
| Zdroj: | Egyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-11 (2021) The Egyptian Journal of Medical Human Genetics |
| ISSN: | 2090-2441 |
| Popis: | Background The novel coronavirus SARS-CoV-2 is currently a global threat to health and economies. Therapeutics and vaccines are in rapid development; however, none of these therapeutics are considered as absolute cure, and the potential to mutate makes it necessary to find therapeutics that target a highly conserved regions of the viral structure. Results In this study, we characterized an essential but poorly understood coronavirus accessory X4 protein, a core and stable component of the SARS-CoV family. Sequence analysis shows a conserved ~ 90% identity between the SARS-CoV-2 and previously characterized X4 protein in the database. QMEAN Z score of the model protein shows a value of around 0.5, within the acceptable range 0–1. A MolProbity score of 2.96 was obtained for the model protein and indicates a good quality model. The model has Ramachandran values of φ = − 57o and ψ = − 47o for α-helices and values of φ = − 130o and ψ = + 140o for twisted sheets. Conclusions The protein data obtained from this study provides robust information for further in vitro and in vivo experiment, targeted at devising therapeutics against the virus. Phylogenetic analysis further supports previous evidence that the SARS-CoV-2 is positioned with the SL-CoVZC45, BtRs-BetaCoV/YN2018B and the RS4231 Bat SARS-like corona viruses. |
| Databáze: | OpenAIRE |
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