HLA DRB1*DQB1* haplotype in HTLV-I-associated familial infective dermatitis may predict development of HTLV-I-associated myelopathy/tropical spastic paraparesis
| Autor: | Clarence J. Gibbs, Windell Miller, Barrie Hanchard, Angela Manns, Ernest Pate, Pamela Rodgers-Johnson, Lois Lagrenade, Shinji Yashiki, Toshinobu Fujiyoshi, Michelle Blank, Shunro Sonoda, Beverley Cranston |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Jamaica Genotype Dermatitis Human leukocyte antigen Major histocompatibility complex Myelopathy immune system diseases Predictive Value of Tests HLA-DQ Antigens Tropical spastic paraparesis medicine HLA-DQ beta-Chains Humans Skin Diseases Infectious Child HLA-DRB1 Genetics (clinical) biology business.industry Histocompatibility Testing Haplotype virus diseases HLA-DR Antigens medicine.disease HTLV-I Infections Paraparesis Tropical Spastic Pedigree Haplotypes Child Preschool Immunology biology.protein Htlv i associated myelopathy Female Viral disease business HLA-DRB1 Chains |
| Zdroj: | American journal of medical genetics. 61(1) |
| ISSN: | 0148-7299 |
| Popis: | A possible causal association between infective dermatitis and HTLV-I infection was reported in 1990 and confirmed in 1992. We now report familial infective dermatitis (ID) occurring in a 26-year-old mother and her 9-year-old son. The mother was first diagnosed with ID in 1969 at the age of 2 years in Dermatology Unit at the University Hospital of the West Indies (U.H.W.I.) in Jamacia. The elder of her 2 sons was diagnosed with ID at the age of 3 years, also at U.H.W.I. Both mother and son are HTLV-I-seropositive. A second, younger son, currently age 2 years, is also HTLV-I-seropositive, but without clinical evidence of ID. Major histocompatibility complex (MHC), class II, human leucocyte antigen (HLA) genotyping documented a shared class II haplotype, DRB1*DQB1* (1101-0301), in the mother and her 2 sons. This same haplotype has been described among Japanese patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and has been associated with a possible pathologically heightened immune response to HTLV-I infection. The presence of this haplotype in these familial ID cases with clinical signs of HAM/TSP may have contributed to their risk for development of HAM/TSP. The unaffected, HTLV-I-seropositive, younger son requires close clinical follow-up. 20 refs., 1 fig., 1 tab. |
| Databáze: | OpenAIRE |
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