Progression of subclinical atherosclerosis in subjects with rheumatoid arthritis and the metabolic syndrome

Autor: Manuel Castro Cabezas, Benjamin Burggraaf, Boudewijn Klop, Noelle van der Meulen, Lenneke Prinzen, Marijke A. de Vries, Erwin Birnie, Deborah F. van Breukelen-van der Stoep, Gert-Jan M van de Geijn, Jende van Zeben
Rok vydání: 2017
Předmět:
Adult
Carotid Artery Diseases
Male
medicine.medical_specialty
Time Factors
Carotid Artery
Common
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
Risk Assessment
Arthritis
Rheumatoid
03 medical and health sciences
0302 clinical medicine
Risk Factors
Diabetes mellitus
Internal medicine
medicine
Prevalence
Humans
Hypoglycemic Agents
cardiovascular diseases
Prospective Studies
Antihypertensive Agents
Aged
Hypolipidemic Agents
Netherlands
030203 arthritis & rheumatology
Metabolic Syndrome
business.industry
Middle Aged
medicine.disease
Plaque
Atherosclerotic
Increased risk
Treatment Outcome
Intima-media thickness
Subclinical atherosclerosis
Rheumatoid arthritis
Antirheumatic Agents
Usual care
Asymptomatic Diseases
cardiovascular system
Disease Progression
Female
Metabolic syndrome
Cardiology and Cardiovascular Medicine
business
Risk Reduction Behavior
Cohort study
Zdroj: Atherosclerosis. 271
ISSN: 1879-1484
Popis: BACKGROUND AND AIMS Rheumatoid arthritis (RA) has been associated with an increased risk of atherosclerosis. We aimed to evaluate the progression of carotid intima media thickness (cIMT) in RA patients subject to a cardiovascular treat-to-target intervention. In addition, the presence of the metabolic syndrome (MetS) on cIMT outcomes was evaluated. METHODS We performed a cohort analysis of FRANCIS, in which RA patients ≤70 years without CVD or diabetes mellitus were randomized for either a treat-to-target intervention or usual care concerning CVD risk factors. MetS was scored at baseline. RESULTS Three-year data was available in 212 well-controlled RA patients. The treat-to-target intervention resulted in a lower cIMT progression over three years compared to the usual care. However, there was no difference in cIMT at three years between groups. MetS was present in 40.1% of RA patients. Baseline cIMT was significantly higher in RA patients with MetS compared to those without (0.619 (0.112) versus 0.557 (0.104) mm; p
Databáze: OpenAIRE
Externí odkaz: