Effect of D-amphetamine on the behaviour of rats in the open field apparatus: Interaction with four neuroleptics and changes in biogenic amine metabolsm in discrete brain regions
| Autor: | Marina A. Lynch, Marie Kenny, Brian E. Leonard |
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| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Dextroamphetamine Chlorpromazine Dopamine Striatum Limbic system Internal medicine Biogenic amine medicine Animals Amphetamine Brain Chemistry chemistry.chemical_classification Behavior Animal business.industry Tryptophan General Medicine Rats medicine.anatomical_structure Endocrinology nervous system chemistry Anesthesia Licking business medicine.drug |
| Zdroj: | Irish Journal of Medical Science. 147:337-350 |
| ISSN: | 1863-4362 0021-1265 |
| Popis: | An acute dose of D-amphetamine (5 mg/kg) caused marked stereotyped licking, sniffing and gnawing, and hyperactivity. These effects were prevented by chlorpromazine. DOPAC and HVA were assessed in 4 brain areas (striatum, amygdaloid cortex, olfactory lobes and brain stem) following the administration of these drugs. It was found that the amphetamine-induced changes in dopamine metabolism in both the striatum and olfactory lobes returned to control levels following chlorpromazine treatment. It is suggested that the behavioural changes induced by amphetamine are a consequence of changes in dopamine metabolism in both the striatum and mesolimbic systems. The acute administration of amphetamine also caused an increase in the concentration of tryptophan and 5-HT in the brain stem, striatum and some regions of the limbic system. Chlorpromazine also raised the concentrations of these substances when given alone but in combination with ampheeamine reduced the concentration of 5-HT to control values in the striatum, olfactory lobes and amygdaloid cortex but raised it in the brain stem. Thus 5-HT may play an ancillary role in amphetamine induced behavioural changes. |
| Databáze: | OpenAIRE |
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