Collagen I and III and mechanical properties of conduit arteries in rats with genetic hypertension
| Autor: | M. Legrand, J. Sassard, Ph. Chamiot Clerc, Michel E. Safar, Bernard I. Levy, J.F. Renaud, J.L. Samuel, Jacques Blacher |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Physiology Hemodynamics Rats Inbred WKY Muscle hypertrophy Isomerism Internal medicine medicine.artery Rats Inbred SHR medicine Animals RNA Messenger Aorta In Situ Hybridization biology business.industry Rats Inbred Strains Anatomy medicine.disease Elasticity Rats medicine.anatomical_structure Endocrinology Carotid Arteries Circulatory system Hypertension cardiovascular system biology.protein Arterial stiffness Collagen Cardiology and Cardiovascular Medicine business Elastin Blood vessel Artery |
| Zdroj: | Journal of vascular research. 36(2) |
| ISSN: | 1018-1172 |
| Popis: | Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneously hypertensive rats) and Lyon (normotensive and hypertensive rats) origin were studied. The stiffness of the carotid wall material (ultrasound), the histomorphometry of the aortic wall with the content in collagen I and III subtypes and their corresponding mRNA were analyzed. Independently of hypertension, the Japanese group differed from the Lyon group by a stiffer carotid wall material at any given value of wall stress; a lesser degree of aortic hypertrophy with a higher percentage of elastin, and a higher density of collagen III but not of collagen I. All other hemodynamic and histomorphometric parameters were affected by both the origin of the rats (Japanese vs. Lyon) and the presence of hypertension. Large artery stiffness in genetically hypertensive rats was not only influenced by hypertension itself, but also by differences in the contents of collagen subtypes which are also found in their corresponding normotensive controls. |
| Databáze: | OpenAIRE |
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