Selective Methylation of Histone H3 Variant H3.1 Regulates Heterochromatin Replication

Autor: Philipp Voigt, Danny Reinberg, Yannick Jacob, Mark T.A. Donoghue, Chantal LeBlanc, Charles J Underwood, Joseph S. Brunzelle, Vanessa Mongeon, Jean-François Couture, Robert A. Martienssen, E. Bergamin, Scott D. Michaels
Přispěvatelé: Cold Spring Harbor Laboratory (CSHL), University of Ottawa [Ottawa], Northwestern Synchrotron Research Center (NSRC), Northwestern Synchrotron, Indiana University [Bloomington], Indiana University System, New York University School of Medicine (NYU), New York University School of Medicine, NYU System (NYU)-NYU System (NYU)
Rok vydání: 2014
Předmět:
DNA Replication
Threonine
[SDV]Life Sciences [q-bio]
Molecular Sequence Data
Arabidopsis
Mitosis
MESH: Catalytic Domain
MESH: DNA Replication
MESH: Amino Acid Sequence
MESH: Arabidopsis Proteins
Biology
Crystallography
X-Ray
Methylation
Article
Epigenesis
Genetic
Histones
MESH: Methylation
Histone H3
Histone H1
Gene Expression Regulation
Plant
Catalytic Domain
Heterochromatin
MESH: Methyltransferases
Histone methylation
Histone H2A
Histone code
MESH: Arabidopsis
Amino Acid Sequence
MESH: Epigenesis
Genetic
MESH: Threonine
MESH: Gene Expression Regulation
Plant
Conserved Sequence
MESH: Histones
Genetics
MESH: Molecular Sequence Data
MESH: Conserved Sequence
Multidisciplinary
Arabidopsis Proteins
EZH2
Methyltransferases
MESH: Mitosis
MESH: Crystallography
X-Ray
3. Good health
MESH: Heterochromatin
MESH: Protein Processing
Post-Translational
Histone methyltransferase
Heterochromatin protein 1
Protein Processing
Post-Translational
Zdroj: iScience
iScience, Elsevier, 2014, 343 (6176), pp.1249-1253. ⟨10.1126/science.1248357⟩
ISSN: 1095-9203
0036-8075
2589-0042
DOI: 10.1126/science.1248357
Popis: Making a Histone Mark The covalent marks on histones (the principal components of chromatin) play a critical role in the regulation of gene expression. Somehow these marks are preserved when a cell in a tissue divides so that the daughter cells maintain the gene expression program and tissue identity of the parent cell. Jacob et al. (p. 1249 ) show that the Arabidopsis histone methylase ATXR5 is specific for the replication-dependent histone variant H3.1 and maintains the repressive histone H3 lysine-27 methyl mark on the H3.1 variant during genome replication, thus, preserving cell-type–specific regions of heterochromatin and gene repression through cell division and beyond.
Databáze: OpenAIRE
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