Administration of granulocyte colony-stimulating factor facilitates the regenerative process of injured mice skeletal muscle via the activation of Akt/GSK3αβ signals
| Autor: | Toshihito Naito, Tatsuo Akema, Yoshinobu Ohira, Toshitada Yoshioka, Moroe Beppu, Takao Sugiura, Katsumasa Goto, Shigeta Morioka, Yusuke Matsuba |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Satellite Cells Skeletal Muscle Physiology Population Biology Granulocyte Glycogen Synthase Kinase 3 Mice Cardiotoxin Physiology (medical) Internal medicine Granulocyte Colony-Stimulating Factor medicine Animals Regeneration Orthopedics and Sports Medicine Muscle Skeletal education Protein kinase B education.field_of_study Glycogen Synthase Kinase 3 beta Regeneration (biology) Public Health Environmental and Occupational Health PAX7 Transcription Factor Skeletal muscle General Medicine Regenerative process Granulocyte colony-stimulating factor Mice Inbred C57BL Endocrinology medicine.anatomical_structure Immunology Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | European Journal of Applied Physiology. 105:643-651 |
| ISSN: | 1439-6327 1439-6319 |
| Popis: | Effects of administration of granulocyte colony-stimulating factor (G-CSF) on the regeneration of injured mammalian skeletal muscles were studied in male C57BL/6J mice. Muscle injury was induced by injection of cardiotoxin (CTX) into tibialis anterior muscles bilaterally. G-CSF was administrated for 8 consecutive days from 3 days before and 5 days after the injection. Significant decreases of wet weight and protein content were noted in the necrotic muscle with CTX injection. A large number of the regenerating fibers having central nucleus were observed 7 days after the injection. The regeneration of injured muscle was further facilitated by the G-CSF treatment. Population of Pax7-positive nuclei was increased by the G-CSF treatment at day 7. Phospho-Akt and phospho-glycogen synthase kinase 3alphabeta (GSK3alphabeta) signals were also activated by G-CSF-administrated group during the regenerative process. It was suggested that G-CSF treatment may facilitate the regeneration of injured skeletal muscles via the activation of Akt/GSK3alphabeta signals. |
| Databáze: | OpenAIRE |
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