Optogenetic skeletal muscle-powered adaptive biological machines
| Autor: | Caroline Cvetkovic, Randall Jeffrey Platt, Rashid Bashir, Roger D. Kamm, Sebastien G. M. Uzel, Ritu Raman, Parijat Sengupta |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Computer science Finite Element Analysis Nanotechnology 02 engineering and technology Stimulus (physiology) Optogenetics Time-Lapse Imaging Cell Line Mice 03 medical and health sciences medicine Animals Muscle Skeletal Directional locomotion Multidisciplinary Tissue Engineering business.industry Skeletal muscle Control engineering Equipment Design Robotics Biological Sciences Modular design 021001 nanoscience & nanotechnology Biological materials 030104 developmental biology medicine.anatomical_structure Printing Three-Dimensional Forward engineering 0210 nano-technology business Actuator Locomotion Muscle Contraction |
| Zdroj: | Proceedings of the National Academy of Sciences. 113:3497-3502 |
| ISSN: | 1091-6490 0027-8424 |
| Popis: | Complex biological systems sense, process, and respond to their surroundings in real time. The ability of such systems to adapt their behavioral response to suit a range of dynamic environmental signals motivates the use of biological materials for other engineering applications. As a step toward forward engineering biological machines (bio-bots) capable of nonnatural functional behaviors, we created a modular light-controlled skeletal muscle-powered bioactuator that can generate up to 300 µN (0.56 kPa) of active tension force in response to a noninvasive optical stimulus. When coupled to a 3D printed flexible bio-bot skeleton, these actuators drive directional locomotion (310 µm/s or 1.3 body lengths/min) and 2D rotational steering (2°/s) in a precisely targeted and controllable manner. The muscle actuators dynamically adapt to their surroundings by adjusting performance in response to "exercise" training stimuli. This demonstration sets the stage for developing multicellular bio-integrated machines and systems for a range of applications. |
| Databáze: | OpenAIRE |
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