Tumour necrosis factor alpha secretion in leporine endotoxaemia: role of the liver and effects of hepatic ischaemia
| Autor: | I. L. R. Badger, J. A. C. Buckels, P. Townsend |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Lipopolysaccharides
medicine.medical_specialty Time Factors Lipopolysaccharide Ischemia Mesenteric Vein chemistry.chemical_compound Mesenteric Veins Internal medicine Escherichia coli medicine Animals Secretion Vein Lagomorpha biology Tumor Necrosis Factor-alpha business.industry Gastroenterology medicine.disease biology.organism_classification Peripheral Endotoxins Endocrinology medicine.anatomical_structure Liver chemistry Injections Intravenous Immunology Female Tumor necrosis factor alpha Rabbits business Research Article |
| Zdroj: | Gut. 33:694-697 |
| ISSN: | 0017-5749 |
| DOI: | 10.1136/gut.33.5.694 |
| Popis: | A leporine model to investigate tumour necrosis factor alpha (TNF alpha) secretion after peripheral vein or mesenteric vein lipopolysaccharide injection was devised. Mesenteric vein injection provoked lower arterial concentrations after 90 minutes (median (range), 2.81, (0.75-11.96) ng/ml) than peripheral vein injection (7.00 (4.27-14.95) ng/ml (p less than 0.05)). Mesenteric vein injection after 10 minutes' warm hepatic ischaemia, which impairs hepatic clearance, provoked higher median arterial TNF alpha values at 90 minutes (7.98 (2.85-21.48) ng/ml) than in normal animals (p less than 0.05). Portal vein endotoxaemia induced less TNF alpha production than systemic endotoxaemia unless hepatic clearance was impaired, thus the major source of TNF alpha in systemic endotoxaemia is probably extrahepatic. |
| Databáze: | OpenAIRE |
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