Markers of Endothelial Dysfunction: E-selectin, Endothelin-1 and von Willebrand Factor in Patients with Coronary Heart Disease, Including in Combination with Type 2 Diabetes Mellitus
| Autor: | Yu N Belenkov, N V Khabarova, A O Iusupova, E. V. Privalova, A. V. Zhito |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
diabetes mellitus type 2 Type 2 diabetes RM1-950 endothelial dysfunction e-selectin Von Willebrand factor Internal medicine E-selectin medicine Diseases of the circulatory (Cardiovascular) system Pharmacology (medical) Endothelial dysfunction biology Cell adhesion molecule business.industry Type 2 Diabetes Mellitus medicine.disease Endothelin 1 ischemic heart disease von willebrand factor RC666-701 endothelin-1 biology.protein Cardiology Therapeutics. Pharmacology medicine.symptom Cardiology and Cardiovascular Medicine business Vasoconstriction |
| Zdroj: | Racionalʹnaâ Farmakoterapiâ v Kardiologii, Vol 15, Iss 6, Pp 892-899 (2020) |
| ISSN: | 2225-3653 1819-6446 |
| Popis: | The prevalence of coronary heart disease (CHD) and type 2 diabetes mellitus (type 2 diabetes) in Russia and in the world continues to increase. Despite the prevention and optimization of therapy, CHD retains its leadership among all causes of death, and the mortality rate from type 2 diabetes and its complications gradually increases too. To improve the treatment of the above mentioned diseases, it is necessary to clarify the pathogenetic mechanisms of their development. The formation of endothelial dysfunction, characterized by an increase in the level of cell adhesion molecules and vasoconstriction, is a common link characteristic for the course and progression of CHD and type 2 diabetes. This article presents an analysis of preand clinical studies on the role of endothelial dysfunction markers: cell adhesion molecules (E-selectin), vasoconstriction (endothelin-1) and von Willebrand factor in patients with CHD, including those with type 2 diabetes mellitus. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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