Stereoselective Synthesis of the Axially Chiral A−B Ring System of Vancomycin Utilizing a Planar Chiral Arene Chromium Complex

Autor:	Suguru Sugimoto, Motokazu Uemura, Atsushi Tachibana, Ken Kamikawa
Rok vydání:	2001
Předmět:	CHROMIUM COMPLEX Stereochemistry Organic Chemistry Molecular Conformation chemistry.chemical_element Ring (chemistry) Biochemistry Anti-Bacterial Agents Chromium Planar chemistry Vancomycin Chromium Compounds Stereoselectivity Physical and Theoretical Chemistry Enantiomer Axial symmetry
Zdroj:	Organic Letters. 3:2033-2036
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol010076f
Popis:	[reaction: see text] The axial biaryl ring system of vancomycin was stereoselectively synthesized by utilizing a planar chiral tricarbonyl(arylhalide)chromium complex. Both enantiomers of the planar chiral (arylbromide)chromium complexes, (+)-9 and ent-(-)-9, can be stereoselectively transferred to an absolutely identical key intermediate 23 for the vancomycin A-B ring system by the diastereoselective Suzuki-Miyaura cross-coupling reaction as key step.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda9df650a124137d84fb24f57669256 https://doi.org/10.1021/ol010076f Zobrazit plný text záznamu