Atopic Dermatitis and Sensitisation to Molecular Components of Alternaria, Cladosporium, Penicillium, Aspergillus, and Malassezia—Results of Allergy Explorer ALEX 2
Autor: | Ctirad Andrys, Jarmila Čelakovská, Radka Vankova, Jan Krejsek, Eva Cermakova, Josef Bukac |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Microbiology (medical)
Allergy Cladosporium Plant Science medicine.disease_cause Immunoglobulin E ALEX 2–Allergy Explorer Article Malassezia 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Allergen medicine lcsh:QH301-705.5 Ecology Evolution Behavior and Systematics Sensitization Asthma allergic rhinitis biology atopic dermatitis business.industry Penicillium Alternaria Atopic dermatitis biology.organism_classification medicine.disease molecular components Aspergillus medicine.anatomical_structure lcsh:Biology (General) 030228 respiratory system Immunology biology.protein bronchial asthma business |
Zdroj: | Journal of Fungi Journal of Fungi, Vol 7, Iss 183, p 183 (2021) Volume 7 Issue 3 |
ISSN: | 2309-608X |
Popis: | Progress in laboratory diagnostics of IgE-mediated allergies is being made through the use of component-resolved diagnosis. The aim of our study is to analyze the sensitization profile to allergen reagents in patients suffering from atopic dermatitis with the use of the ALEX 2–Allergy Explorer and especially to show the sensitization to molecular components of molds and yeast. The complete dermatological and allergological examination including the examination of the sensitization to allergen reagents with Allergy Explorer ALEX 2 testing was performed. The relation between the sensitization to molecular components of molds and yeast and the severity of atopic dermatitis, and the occurrence of bronchial asthma and allergic rhinitis was evaluated. Altogether, 100 atopic dermatitis patients were examined—48 men and 52 women, with an average age of 40.9 years. The sensitization to Mala s 6, Mala s 11, Sac c, Asp f 6, Cla h and Cla h 8 correlates to the severity of atopic dermatitis. The sensitization to Sac c, Alt a 6, Cla h, Cla h 8 was observed significantly more frequently in patients suffering from bronchial asthma to Mala s 6 in patients suffering from allergic rhinitis. In patients with severe form of atopic dermatitis (AD), a very high level of specific IgE was recorded to Mala s 11 (in 36%) and to Asp f 6 (in 12%). |
Databáze: | OpenAIRE |
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