Changes in the Steady-State Potential in Rats with Focal Cerebral Ischemia Receiving Cyclopentyladenosine
| Autor: | Albert Sufianov, M. Taborov, Shapkin Ag, G Z Sufianova, Usov La, S E Murik |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Adenosine Time Factors Steady state (electronics) Cerebral arteries Ischemia Action Potentials Infarction Neuroprotection General Biochemistry Genetics and Molecular Biology Brain Ischemia Parietal Lobe Occlusion medicine Animals business.industry Nervous tissue Infarction Middle Cerebral Artery General Medicine medicine.disease Rats Disease Models Animal Neuroprotective Agents medicine.anatomical_structure Anesthesia Negative potential Female business Microelectrodes |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 136:576-578 |
| ISSN: | 0007-4888 |
| Popis: | Brain function and neuroprotective activity of cyclopentyladenosine in rats with focal cerebral ischemia were evaluated by recording the steady-state potential. Cerebral ischemia was modeled by intravasal occlusion of the left internal carotid and middle cerebral arteries and bilateral occlusion of the common carotid arteries. Recording of the steady-state brain potential during experimental ischemia allowed identifying the development of ischemic depolarization by a negative potential shift. Changes in the steady-state potential after cyclopentyladenosine administration reflected delayed development of ischemic depolarization in the nervous tissue. Cyclopentyladenosine holds much promise for the protection of nerve cells from ischemic injury. |
| Databáze: | OpenAIRE |
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