Mizoribine protects against bleomycin-induced lung injury
| Autor: | Makoto Terada, Hajime Sano, Naoto Azuma, Haruki Okamura, Haruyasu Ueda, Kiyoshi Matsui |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Pathology medicine.medical_specialty Time Factors Pulmonary Fibrosis Cell Count Inflammation Lung injury Bleomycin Mice chemistry.chemical_compound Rheumatology Fibrosis Pulmonary fibrosis Animals Medicine Lymphocytes Lung Cell Proliferation Antibiotics Antineoplastic Mizoribine medicine.diagnostic_test urogenital system business.industry Macrophages nutritional and metabolic diseases respiratory system medicine.disease respiratory tract diseases Mice Inbred C57BL Disease Models Animal Hydroxyproline Bronchoalveolar lavage chemistry Female Ribonucleosides medicine.symptom Lung Diseases Interstitial business Bronchoalveolar Lavage Fluid Infiltration (medical) Immunosuppressive Agents medicine.drug |
| Zdroj: | Modern Rheumatology. 20:471-477 |
| ISSN: | 1439-7609 1439-7595 |
| DOI: | 10.1007/s10165-010-0312-8 |
| Popis: | Bleomycin (BLM)-induced lung injury has become a model for studies of interstitial pneumonitis and pulmonary fibrosis. BLM induces lung injury in two phases: early inflammation characterized by infiltration of inflammatory cells into the lungs, followed by a late phase of fibrosis characterized by deposition of collagen. In this study, we examined the role of mizoribine (MZB) in the regulation of inflammatory tissue injury caused by BLM. We examined the role of MZB using a mouse model of BLM-induced lung injury. We demonstrated that mice subjected to instillation of BLM into the lungs had a significantly increased number of macrophages and lymphocytes in bronchoalveolar lavage fluid (BALF), but that those treated with MZB in the early phase showed a significant reduction in the total number of BALF macrophages and lymphocytes. However, MZB was unable to inhibit fibrosis in the late phase of BLM injury. Our findings suggest that MZB inhibits the proliferation of both lymphocytes and macrophages in the early phase of the BLM-induced acute inflammatory response, as well as its development and amplification, but does not inhibit fibrotic change in the late phase. |
| Databáze: | OpenAIRE |
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