Quinolone Complexes with Lanthanide Ions: An Insight into their Analytical Applications and Biological Activity
| Autor: | Alexandra-Cristina Munteanu, Ana-Mădălina Măciucă, Valentina Uivarosi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
DNA Topoisomerase IV
Lanthanide Metal ions in aqueous solution Pharmaceutical Science biological activity Review metal complexes Quinolones Lanthanoid Series Elements Analytical Chemistry Ion Metal lcsh:QD241-441 lcsh:Organic chemistry Ciprofloxacin Computational chemistry Ionization Drug Discovery Molecule lanthanides Physical and Theoretical Chemistry fluoroquinolones Binding Sites Chemistry Organic Chemistry Biological activity DNA Chemistry (miscellaneous) visual_art visual_art.visual_art_medium Molecular Medicine quantitative determination Absorption (chemistry) |
| Zdroj: | Molecules, Vol 25, Iss 6, p 1347 (2020) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Quinolones comprise a series of synthetic bactericidal agents with a broad spectrum of activity and good bioavailability. An important feature of these molecules is their capacity to bind metal ions in complexes with relevant biological and analytical applications. Interestingly, lanthanide ions possess extremely attractive properties that result from the behavior of the internal 4f electrons, behavior which is not lost upon ionization, nor after coordination. Subsequently, a more detailed discussion about metal complexes of quinolones with lanthanide ions in terms of chemical and biological properties is made. These complexes present a series of characteristics, such as narrow and highly structured emission bands; large gaps between absorption and emission wavelengths (Stokes shifts); and long excited-state lifetimes, which render them suitable for highly sensitive and selective analytical methods of quantitation. Moreover, quinolones have been widely prescribed in both human and animal treatments, which has led to an increase in their impact on the environment, and therefore to a growing interest in the development of new methods for their quantitative determination. Therefore, analytical applications for the quantitative determination of quinolones, lanthanide and miscellaneous ions and nucleic acids, along with other applications, are reviewed here. |
| Databáze: | OpenAIRE |
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