Arterial stiffness predicts risk for long-term recurrence in patients with type 2 diabetes admitted for acute coronary event
| Autor: | Georgios Koukoulis, Filippos Triposkiadis, Stefanos G. Foussas, Ioannis Skoularigis, Antonios Destounis, Dimitrios Levisianou, Elias Skopelitis, Evdokia N. Adamopoulou, Andreas Melidonis, Theodora Xenopoulou |
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| Rok vydání: | 2013 |
| Předmět: |
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medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Myocardial Infarction Kaplan-Meier Estimate Type 2 diabetes Pulse Wave Analysis Ventricular Function Left Vascular Stiffness Endocrinology Recurrence Internal medicine Angioplasty Internal Medicine medicine Humans Medical history Prospective Studies cardiovascular diseases Myocardial infarction Acute Coronary Syndrome Pulse wave velocity Aged Ejection fraction business.industry General Medicine Middle Aged Prognosis medicine.disease Hospitalization Diabetes Mellitus Type 2 Heart failure Arterial stiffness Cardiology Female business |
| Zdroj: | Diabetes Research and Clinical Practice. 99:315-320 |
| ISSN: | 0168-8227 |
| DOI: | 10.1016/j.diabres.2012.11.023 |
| Popis: | Objectives to investigate the predictive value of arterial stiffness (AS) estimation for long-term recurrences in patients with type 2 diabetes (DM2) following acute coronary event. Patients and methods prospective observational study involving 119 DM2 patients without history of coronary heart disease admitted with ST-segment elevation myocardial infarction (STEMI). Medical history, anthropometrics, smoking, HbA1c, lipid profile, troponine-I levels, and left ventricular ejection fraction (LVEF) were recorded. Carotid-femoral pulse wave velocity (cf-PWV) was measured 1 month after discharge. Patients were followed up for 36 months or to reach an end-point: cardiovascular death, acute coronary event, angioplasty or hospitalization for acute heart failure. To facilitate analysis, patients were divided into two groups according to cf-PWV, using the accepted cut-off value of 12m/s. Results overall, 34 patients had a recurrence. In Kaplan–Meier analysis patients with cf-PWV>12m/s had mean time-to-event 353±43 days compared to 505±115 days for patients with cf-PWV≤12m/s, log rank=0.0252. In multivariate analysis factors independently associated with recurrence were age (66.53±6.87 vs. 61.54±10.77 years, p =0.015), LVEF (41.66±8.21 vs. 47.58±8.11%, p =0.001) and cf-PWV (13.94±2.91 vs. 12.35±2.77m/s, p =0.008). Conclusions AS estimation in patients with DM2 after STEMI discriminate patients at higher risk for 3-year recurrence, and maybe valuable for distinguishing patients likely to require a more rigorous therapeutic intervention. |
| Databáze: | OpenAIRE |
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