Human platelets secrete chemotactic activity for eosinophils
| Autor: | J A, Burgers, R C, Schweizer, L, Koenderman, P L, Bruijnzeel, J W, Akkerman |
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| Rok vydání: | 1993 |
| Předmět: |
Blood Platelets
Platelet Storage Pool Deficiency Chemotactic Factors Immunology Azepines Prostaglandin Endoperoxides Cell Biology Hematology Triazoles Cytoplasmic Granules Platelet Factor 4 Biochemistry Adenosine Diphosphate Eosinophils Chemotaxis Leukocyte Thromboxane A2 Adenosine Triphosphate Cytosol Humans Calcium Platelet Activating Factor |
| Zdroj: | Blood. 81:49-55 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v81.1.49.bloodjournal81149 |
| Popis: | Thrombin-stimulated platelets liberate factors that induce chemotaxis of eosinophils and raise their cytosolic Ca2+ content ([Ca2+]i). The sources of this activity are the dense- and alpha-granules because inhibition of prostaglandin endoperoxide/thromboxane A2 formation and the platelet-activating factor receptor-antagonist WEB 2086 have no effect. Platelets from patients with Storage-Pool Deficiency show about 60% of the normal chemotactic activity with little effect on [Ca2+]i, whereas completely degranulated platelets fail to affect eosinophils. In concentrations secreted by the platelets, adenosine diphosphate (ADP), and platelet factor 4 have no effect, whereas adenosine triphosphate (ATP) induces a strong chemotactic response and increases [Ca2+]i. However, apart from ATP other modulating factors must be involved as platelet releasates induce more chemotaxis than ATP alone. Thus, platelets secrete factors that activate eosinophils and may contribute to inflammatory and allergic processes. |
| Databáze: | OpenAIRE |
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