DNA Methylation and gene expression patterns are widely altered in fetal growth restriction and associated with FGR development
| Autor: | Su Han Cho, Kwoneel Kim, Young Nam Kim, DoHwa Im, Ji-Yeon Kim, Seoyeong Lee, Jeong Hyun Kim |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Medicine (General) INS QH301-705.5 and ZFP36L2 Type 2 diabetes Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences R5-920 0302 clinical medicine Gene expression medicine Fetal growth Biology (General) MEG3 Omics & Bioinformatics Genetics Fetus DNA methylation Fetal growth restriction medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis embryonic structures Animal Science and Zoology Research Article |
| Zdroj: | Animal Cells and Systems article-version (VoR) Version of Record Animal Cells and Systems, Vol 25, Iss 3, Pp 128-135 (2021) |
| DOI: | 10.6084/m9.figshare.14607396 |
| Popis: | Fetal growth restriction (FGR) is the failure of the fetus toachieve its genetically determined growth potential, which increasesrisks for a variety of genetic diseases, such as type 2 diabetes mellitus, coronary artery disease, and stroke, during the lifetime. The dysregulation of DNA methylationis known to interact with environmental fluctuations, affect gene expressions comprehensively, and be fatal to fetus development in specific cases. Therefore, we set out to find out epigenetic and transcriptomic alterations associated with FGR development. We found a set of differentially expressed genes associated with differentially methylated regions in placentae and cord blood samples. Using dimensional reduction analysis, the expression and methylation variables of the epigenetically altered genes classified the FGR samples from the controls. These genes were also enriched in the biological pathways such as metabolism and developmental processes related to FGR. Furthermore, three genes of INS, MEG3, and ZFP36L2 are implicated in epigenetic imprinting, which has been associated with FGR. These results strongly suggest that DNA methylation is highly dysregulated during FGR development, and abnormal DNA methylation patterns are likely to alter gene expression. |
| Databáze: | OpenAIRE |
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