The 5-Ws of immunotherapy in head and neck cancer
| Autor: | Mario Occhipinti, Silverio Tomao, Paolo Marchetti, Andrea Botticelli, Valerio M. Napoli, Sasan Amirhassankhani, Bruna Cerbelli, Grazia Sirgiovanni, Christiana Zorica Di Rocco, Federica Mazzuca, Silvia Mezi, Giulia Pomati, Alessandra Emiliani, Marianna Nuti |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Immune checkpoint inhibitors medicine.medical_treatment Disease head and neck cancer immune checkpoint inhibitors immunosuppressive microenvironment immunotherapy PD-1/PD-L1 axis 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine medicine Tumor Microenvironment Humans Immunologic Factors Tumor microenvironment business.industry Squamous Cell Carcinoma of Head and Neck Head and neck cancer Hematology Immunotherapy medicine.disease Clinical trial 030104 developmental biology Head and Neck Neoplasms 030220 oncology & carcinogenesis Biomarker (medicine) business |
| Popis: | The immune checkpoint inhibitors, a class of drugs able to block immune suppressive pathways in order to prime an anticancer immunity, revolutionized standard of care in platinum-refractory recurrent and/or metastatic head and neck carcinoma (R/M HNSCC). The PD-1/ PD-L1 axis is involved in the genesis, maintenance and progression of HNSCC and represents the target of checkpoint inhibitors. HNSCC is an immunosuppressive disease with a high inflammatory component in tumor microenvironment. Recent clinical trials showed that only a small subset of patients really benefits from immunotherapy. This review aims to highlight the five W-points of immunotherapy: why immunotherapy is promising in HNSCC, what is currently available in daily clinical practice, when immunotherapy can be integrated into the therapeutic strategy, where it can be useful according to predictive response biomarker, who, among patients, could get the best benefit from immunotherapy and how improve the achieved results. |
| Databáze: | OpenAIRE |
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