Sublingual Flunarizine: a New Effective Management of the Migraine Attack. A Comparison versus Ergotamine
| Autor: | Alfonso Leo, Fulvio Sorge, Emanuela Di Stasio, Salvatore Bonuso, Enrico Marano |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Male
Migraine Disorders medicine.medical_treatment Administration Oral Sublingual administration Cinnarizine Random Allocation Ergotamine medicine Humans Flunarizine Clinical Trials as Topic Chemotherapy business.industry Effective management Calcium Channel Blockers medicine.disease Ergotamines Neurology Ergotamine Tartrate Migraine Anesthesia Female Neurology (clinical) Isosorbide dinitrate business medicine.drug |
| Zdroj: | Headache: The Journal of Head and Face Pain. 26:227-230 |
| ISSN: | 1526-4610 0017-8748 |
| DOI: | 10.1111/j.1526-4610.1986.hed2605227.x |
| Popis: | SYNOPSIS Flunarizine was found to be effective in the acute treatment of isosorbide dinitrate induced migraine attacks, when given in a dosage of 10 mg sublingually. The present study consists of two parts: in the first preliminary investigation, 7 out of 8 migraine patients who developed a typical migraine attack after isosorbide dinitrate were relieved of pain within about 10 minutes. On the basis of this result a second, randomized controlled open trial was performed, in which the acute efficacy of flunarizine was compared with ergotamine tartrate, 0.25 mg i.m., on 40 migraine patients. Flunarizine was found as effective as ergotamine (75% positive responses in the flunarizine group, 70% in the ergotamine group). The mean latency of the flunarizine effect was significantly lower than that of the ergotamine ( r < 0.001, Student's t test). Moreover sublingual flunarizine was found to be virtually devoid of side effects. |
| Databáze: | OpenAIRE |
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