Sex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure
| Autor: | Ilja M.J. Saris, P. J. W. Pouwels, Julie Bakker, Dick J. Veltman, P. T. Cohen-Kettenis, J. van Hemmen |
|---|---|
| Přispěvatelé: | Netherlands Institute for Neuroscience (NIN), Psychiatry, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health, Medical psychology, Amsterdam Neuroscience - Brain Imaging, Anatomy and neurosciences, Physics and medical technology, Amsterdam Neuroscience - Cellular & Molecular Mechanisms |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent medicine.drug_class Cognitive Neuroscience Statistics Nonparametric Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Sex hormone-binding globulin Complete androgen insensitivity syndrome Internal medicine Fractional anisotropy Image Processing Computer-Assisted medicine Journal Article Humans Gonadal Steroid Hormones Gonadal Dysgenesis 46 XY Brain Mapping Sex Characteristics Sexual differentiation biology Androgen-Insensitivity Syndrome Androgen medicine.disease White Matter Androgen receptor Diffusion Tensor Imaging 030104 developmental biology Endocrinology biology.protein Anisotropy Female Androgen insensitivity syndrome Psychology 030217 neurology & neurosurgery Sex characteristics |
| Zdroj: | Van Hemmen, J, Saris, I M J, Cohen-Kettenis, P T, Veltman, D J, Pouwels, P J W & Bakker, J 2017, ' Sex Differences in White Matter Microstructure in the Human Brain Predominantly Reflect Differences in Sex Hormone Exposure ', Cerebral Cortex, vol. 27, no. 5, pp. 2994-3001 . https://doi.org/10.1093/cercor/bhw156 Cerebral Cortex, 27(5), 2994-3001. Oxford University Press |
| ISSN: | 1047-3211 |
| Popis: | Sex differences have been described regarding several aspects of human brain morphology; however, the exact biological mechanisms underlying these differences remain unclear in humans. Women with the complete androgen insensitivity syndrome (CAIS), who lack androgen action in the presence of a 46,XY karyotype, offer the unique opportunity to study isolated effects of sex hormones and sex chromosomes on human neural sexual differentiation. In the present study, we used diffusion tensor imaging to investigate white matter (WM) microstructure in 46,XY women with CAIS (n = 20), 46,XY comparison men (n = 30), and 46,XX comparison women (n = 30). Widespread sex differences in fractional anisotropy (FA), with higher FA in comparison men than in comparison women, were observed. Women with CAIS showed female-typical FA throughout extendedWMregions, predominantly due to female-typical radial diffusivity. These findings indicate a predominant role of sex hormones in the sexual differentiation ofWMmicrostructure, although sex chromosomegenes and/or masculinizing androgen effects not mediated by the androgen receptor might also play a role. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|