Hyperpotassemia and Bradycardia in a Bedridden Elderly Woman with Selective Hypoaldosteronism Associated with Low Renin Activity
| Autor: | Satoshi Hashimoto, Chihiro Imai, Keiko Iwasaki, Mitsuo Inada |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Bradycardia Aging medicine.medical_specialty Plasma renin activity Gastroenterology Asymptomatic Renin-Angiotensin System Electrocardiography chemistry.chemical_compound Internal medicine Renin Internal Medicine medicine Humans Aldosterone Aged Aged 80 and over Nonsteroidal medicine.diagnostic_test business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine medicine.disease Hypoaldosteronism Endocrinology chemistry Renal potassium excretion Potassium Hyperkalemia Female medicine.symptom business |
| Zdroj: | Internal Medicine. 49:307-313 |
| ISSN: | 1349-7235 0918-2918 |
| Popis: | A bedridden 85-year-old woman had hyperpotassemia (7.7 mEq/L) and bradycardia (30/min). Endocrinologic findings revealed a decrease in the renin-aldosterone system and normal adrenoglucocorticoid function. The results were consistent with the abnormalities seen in selective hypoaldosteronism with low renin activity. In addition, 9 of 11 patients, selected randomly from 72 bedridden elderly patients with normal serum sodium and potassium levels in our hospital, had diminished plasma renin activity (PRA) and plasma aldosterone concentration (PAC). The present patient was prescribed nonsteroidal anti-inflammatory drug (NSAID). NSAID reduces renal potassium excretion through the inhibition of renal prostaglandin synthesis. Therefore, the use of NSAID in bedridden elderly patients might intensify the underlying asymptomatic hypoaldosteronism and cause life-threatening hyperpotassemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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