Exposure to metal fumes and circulating miRNAs in Algerian welders
| Autor: | Imene Amrani, Nahida Haddam, Hafeda Merzouk, Farid Zerimech, Susanna Schraen, Jean-Louis Edmé, Jean-Marc Lo-Guidice, Anne Garat, Abdessalam Taleb, Delphine Allorge |
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| Rok vydání: | 2019 |
| Předmět: |
Circulating mirnas
Adult Chromium Male Urinary system Metal fumes Physiology Renal function Urine Air Pollutants Occupational Mirna expression Nickel Occupational Exposure Medicine Humans Welding business.industry Public Health Environmental and Occupational Health Middle Aged MicroRNAs Cross-Sectional Studies Metals Algeria Case-Control Studies Smoking status Kidney Diseases business Body mass index Biomarkers |
| Zdroj: | International archives of occupational and environmental health. 93(5) |
| ISSN: | 1432-1246 |
| Popis: | A cross-sectional study was conducted in a group of Algerian welders to study the relationship between the exposure to metal particles from welding fumes and the concentration of three circulating miRNAs, miR-21, miR-146a and miR-155, as markers of renal function injury. Characteristics of the subjects and the curriculum laboris were determined by questionnaires. We measured the concentrations of metals in blood and urine samples using ICP-MS. The three circulating miRNAs studied were measured by quantitative PCR. Associations between miRNAs and internal exposure markers were assessed by simple and multiple regression analyses. miR-21 was significantly lower among welders (p = 0.017), compared with controls, adjusted for age, body mass index, smoking status and seniority. Significant adjusted associations were observed between miR-21 or miR-155 and urinary chromium (p = 0.005 or p = 0.041, respectively), miR-146a and urinary nickel (p = 0.019). The results of the multivariate analysis showed that duration of employment was the main factor responsible for the variation of miRNAs among welders. In conclusion, a recent exposure to certain metals, mainly chromium and nickel, appears to be associated to a decrease in plasma expression of miR-21, miR-146a and miR-155. Further larger studies would help to determine the mechanisms of action of metal particles on miRNA expression. |
| Databáze: | OpenAIRE |
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