Biomimetic 'Nanoplatelets' as a Targeted Drug Delivery Platform for Breast Cancer Theranostics
| Autor: | Yang Cao, Jian Fu, Lin Li, Wei Zhang, Haitao Ran, Xingyue Wang, Qiaoqi Chen |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Photothermal Therapy Nanoparticle Breast Neoplasms 02 engineering and technology 030226 pharmacology & pharmacy Theranostic Nanomedicine Photoacoustic Techniques Mice 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Breast cancer Polylactic Acid-Polyglycolic Acid Copolymer Biomimetic Materials Biomimetics Human Umbilical Vein Endothelial Cells medicine Animals Humans General Materials Science Doxorubicin Fluorocarbons Mice Inbred BALB C Antibiotics Antineoplastic biology Optical Imaging CD44 Photothermal effect Photothermal therapy 021001 nanoscience & nanotechnology medicine.disease Nanostructures PLGA Targeted drug delivery chemistry Cancer research biology.protein Female 0210 nano-technology medicine.drug |
| Zdroj: | ACS Applied Materials & Interfaces. 13:3605-3621 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.0c19259 |
| Popis: | Breast cancer is a major threat to health and lives of females. Biomimetic nanotechnology brought brighter hope for early diagnosis and treatment of breast cancer. Here, we proposed a platelet (PLT) membrane-derived strategy for enhanced photoacoustic (PA)/ultrasonic (US)/fluorescence (FL) multimodal imaging and augmented synergistic photothermal/chemotherapeutic efficacy in tumor cells. A PA imaging contrast and photothermal agent, nanocarbons (CNs), a chemotherapeutic and FL material, doxorubicin (DOX), and perfluoropentane (PFP) were coencapsulated into the poly(lactic-co-glycolic) acid (PLGA) skeletons. Then, the PLT membranes were coated onto the PLGA NPs, which were named as "nanoplatelets" (DOX-PFP-CNs@PLGA/PM NPs). The "nanoplatelets", which conserved the structural advantages and inherent properties of PLTs, could not only escape from phagocytosis of macrophages but also actively targeted tumor cells by the way of antigen-antibody interactions between P-selectin on the PM and CD44 receptors of the tumor cells. With CNs and DOX loaded in, these "nanoplatelets" could serve as an excellent contrast agent for PA/FL imaging. Under laser irradiation, the "nanoplatelets" could turn light energy into heat energy. The laser-triggered photothermal effect, on the one hand, could ablate the tumor cells immediately, and on the other hand, could initiate the optical droplet vaporization of PFP, which subsequently enhanced US imaging and promoted the discharge of encapsulated DOX from the "nanoplatelets" for remarkably strengthening photothermal therapeutic power in turn. In this work, as compared with the bare drug-loaded nanoparticles, the "nanoplatelets" exhibited much more accumulation in the tumor cells, demonstrating superior multimodal imaging capability and preferable synergistic therapeutic performance. In conclusion, the "nanoplatelets" could serve as contrast agents for US imaging and PA imaging to guide the therapy. What is more, the bioinspired PLT-derived, targeted, and nontoxic "nanoplatelets", which were exploited for multimodal PA/US/FL imaging-guided synergistic photothermal/chemo therapy, will be of great value to breast cancer theranostics in the days to come. |
| Databáze: | OpenAIRE |
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