Follicular fluid and serum vascular endothelial growth factor, interleukin (IL)-1β and glycodelin concentrations: comparison between long-gonadotropin-releasing hormone (GnRH)-agonist and GnRH-antagonist cycles: a randomized controlled trial

Autor:	Ömer Çolak, Yunus Aydin, Hikmet Hassa, Tugba Isikci
Rok vydání:	2014
Předmět:	Adult endocrine system medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Interleukin-1beta Gonadotropin-releasing hormone Gonadotropin-releasing hormone antagonist Gonadotropin-Releasing Hormone chemistry.chemical_compound Endocrinology Blood serum Clinical Protocols Ovulation Induction Gonadotropin-releasing hormone agonist Internal medicine medicine Humans Glycoproteins Glycodelin Vascular Endothelial Growth Factors business.industry Obstetrics and Gynecology Interleukin Follicular fluid Follicular Fluid Vascular endothelial growth factor Treatment Outcome chemistry Infertility Female business
Zdroj:	Gynecological Endocrinology. 30:734-738
ISSN:	1473-0766 0951-3590
DOI:	10.3109/09513590.2014.929655
Popis:	In this randomized controlled trial, we aimed to examine whether differences exist among patients who underwent assisted reproductive technology treatment with a long-GnRH-agonist compared to a GnRH-antagonist protocol in terms of levels of follicular fluid (FF) and serum concentrations of vascular endothelial growth factor (VEGF), glycodelin and interleukin (IL)-1β on the day of oocyte pick-up (OPU). In 80 infertile couple with male factor or unexplained infertility, 40 women stimulated with GnRH-antagonist protocol and 40 women with the long-GnRH-agonist protocol. FF and blood serum samples were obtained simultaneously from 80 women during the OPU procedure and the concentrations of VEGF, IL-1β and glycodelin were measured with commercially available kits. Concentrations of FF VEGF, IL-1β and glycodelin were not significantly different in the long-GnRH-agonist and GnRH-antagonist groups, and neither were serum concentrations of VEGF, IL-1β and glycodelin. According to our results in at least, we can say that minor differences between these protocols in terms of clinical pregnancy do not depend on VEGF, glycodelin or IL-1β.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd988c9af27d2fdb7442a8999f96d97e https://doi.org/10.3109/09513590.2014.929655 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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