Reduced Hepatic Uptake of Tc-99m Stannous Colloid–Labeled Leukocytes in a Patient with Congenital Hepatic Fibrosis and Alcoholic Liver Disease
| Autor: | Dylan Bartholomeusz, Chong G. Chew, Barry E. Chatterton |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Liver Cirrhosis Male Alcoholic liver disease Pathology medicine.medical_specialty Cirrhosis Spleen Scintigraphy Fibrosis Leukocytes medicine Humans Radiology Nuclear Medicine and imaging Radionuclide Imaging Hepatitis medicine.diagnostic_test Hepatitis Alcoholic business.industry Tin Compounds General Medicine medicine.disease Technetium Compounds medicine.anatomical_structure Liver Portal hypertension Congenital hepatic fibrosis Radiopharmaceuticals business |
| Zdroj: | Clinical Nuclear Medicine. 25:743-746 |
| ISSN: | 0363-9762 |
| Popis: | A 43-year-old man with liver failure caused by alcohol abuse and congenital hepatic fibrosis was examined for intermittent fever of unknown origin. He had portal hypertension, which was complicated in the past by bleeding varices that required a portocaval shunt. There were no localizing symptoms or signs for the fever, and, apart from an elevated leukocyte count, results of investigations including urine and blood cultures, abdominal ultrasound, abdominal magnetic resonance imaging, and endoscopic retrograde cholangiopancreatography were not helpful. A labeled leukocyte scan was obtained with Tc-99m stannous colloid. The 1-, 3-, and 24-hour images showed marked reduction in tracer uptake within the liver, with increased tracer accumulation in an enlarged spleen and marrow. Marked margination of labeled leukocytes in the lungs was also evident, which subsided on the 24-hour image. The focus of inflammation was not identified, and instead the tracer distribution pattem was similar to that on a Tc-99m sulfur colloid scan in a patient with liver failure. The scan appearances presumably represent reduced uptake of free Tc-99m stannous colloid by Kuppfer cells of the failing liver, with a shift in uptake to the reticuloendothelial system of the spleen and marrow. |
| Databáze: | OpenAIRE |
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