Serotonergic ergoline derivatives

Autor:	M. G. Fornaretto, Sergio Mantegani, Carla Caccia, Robert A. McArthur, Gabriele Damiani, Mario Varasi, Enzo Brambilla
Rok vydání:	1998
Předmět:	medicine.drug_class Stereochemistry Clinical Biochemistry Prefrontal Cortex Pharmaceutical Science Adrenergic Carboxamide Serotonergic Binding Competitive Hippocampus Biochemistry Receptors Dopamine Radioligand Assay Structure-Activity Relationship Drug Discovery medicine Animals Ergolines Binding site Molecular Biology Chemistry Alkaloid Organic Chemistry Dopaminergic Receptors Adrenergic alpha In vitro Rats Serotonin Receptor Agonists Ergoline Drug Design Receptors Serotonin Molecular Medicine Indicators and Reagents Receptors Serotonin 5-HT1 medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 8:1117-1122
ISSN:	0960-894X
Popis:	Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepared, and characterised in vitro for their affinity for adrenergic, dopaminergic and serotonergic binding sites. This study particularly examines the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT1A or 5-HT2 affinity and selectivity respectively.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd9833f06b2805b0f0ec83d9de8001db https://doi.org/10.1016/s0960-894x(98)00166-8 Zobrazit plný text záznamu Full Text from ScienceDirect