Elevation of anti-elastin antibody in patients with asthma
| Autor: | Kenya Koyama, Yoshihiko Ueda, Shingo Tokita, Masafumi Arima, Hirokuni Hirata, Yasutsugu Fukushima, Naotatsu Otsuji, Kei Sugitate, Hajime Arifuku, Takayoshi Owada, Tomoshige Wakayama, Kumiya Sugiyama |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
COPD biology business.industry Immunology General Medicine medicine.disease Gastroenterology respiratory tract diseases Allergic inflammation Internal medicine medicine biology.protein Immunology and Allergy Biomarker (medicine) Sputum Antibody medicine.symptom Airway business Elastin Asthma |
| Zdroj: | Asian Pacific Journal of Allergy and Immunology. |
| ISSN: | 2228-8694 0125-877X |
| Popis: | BACKGROUND It is often difficult to differentiate between asthma and chronic obstructive pulmonary disease (COPD), and useful biomarkers are needed for accurate diagnosis. OBJECTIVE We evaluated anti-elastin antibody to identify useful biomarkers for differentiating between a diagnosis of asthma and COPD. METHODS Patients with asthma (male to female ratio = 10/13; mean age, 67.3 years), COPD (16/0; 74.8 years) and controls (8/4; 72.3 years) were enrolled. Samples from sputum and serum were collected and levels of anti-elastin Ab were measured. RESULTS The levels of anti-elastin Ab in sputum were significantly higher in asthma (11.4 ± 7.16 μg/mL) than in COPD (5.82 ± 5.16 μg/mL; P < 0.01), and serum levels in asthma (67.4 ± 29.7 μg/mL) were also significantly higher than in COPD or controls (45.0 ± 12.8 μg/mL; P < 0.05, 38.6 ± 10.4 μg/mL; P < 0.01, respectively). Anti-elastin Ab in sputum showed a positive correlation with smoking in asthma (r2 = 0.218, P < 0.05). However, no significant differences were observed in the levels of anti-elastin Ab and eosinophils, asthma phenotypes, inhaled corticosteroids, or severity in patients with asthma. Elastin was strongly expressed under the airway basement membrane in asthma compared with COPD or the healthy control. CONCLUSIONS Anti-elastin Ab in sputum could be a useful biomarker for COPD and asthma in ever-smokers. In asthma, anti-elastin Ab was recruited to the airways by both airway allergic inflammation and smoking, and it may contribute to the progression of airway remodeling via autoimmune inflammation, but not emphysema, in COPD. |
| Databáze: | OpenAIRE |
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