Familial Aggregation of Pure Tone Hearing Thresholds in an Aging European Population
| Autor: | Anke Tropitzsch, Hannie Kremer, Elina Mäki-Torkko, Cor W. R. J. Cremers, Thomas F. Wienker, Jan Hendrickx, Amalia Diaz-Lacava, Sylvia J. W. Kunst, Martti Sorri, Kelly Demeester, Erik Fransen, Joke Huyghe, Paul Van de Heyning, Patrick L. M. Huygen, Eva Orzan, Els Van Eyken, Guy Van Camp, Jeroen R. Huyghe, Angeles Espeso, Katja Verbruggen, Amanda Bonaconsa, Vedat Topsakal, Agnete Parving, Samuli Hannula, Michael Bille, Ingeborg Dhooge, Mona Jensen, Ilmari Pyykkö, Markus H F Pfister, Dafydd Stephens, Michael Steffens, Manuela Mazzoli, Lut Van Laer |
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| Přispěvatelé: | Specialities, Surgical clinical sciences, Ear, nose & throat, Internal Medicine Specializations, Cardio-vascular diseases |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Hearing Loss/epidemiology Intraclass correlation Presbycusis DCN PAC - Perception action and control Audiometry Pure-Tone/statistics & numerical data Audiology Europe/epidemiology surgery medicine Humans statistics & numerical data [Audiometry Pure-Tone] ddc:610 Hearing Loss Aged Auditory Threshold/physiology Analysis of Variance medicine.diagnostic_test business.industry Age Factors Family aggregation Auditory Threshold epidemiology [Europe] Heritability Middle Aged medicine.disease Genetics and epigenetic pathways of disease Plasticity and memory [NCMLS 6] Sensory Systems Genetics and epigenetic pathways of disease DCN MP - Plasticity and memory [NCMLS 6] Europe physiology [Auditory Threshold] Otorhinolaryngology epidemiology [Hearing Loss] Audiometry Pure-Tone Sensorineural hearing loss Female Human medicine Neurology (clinical) Analysis of variance Pure tone audiometry Audiometry business |
| Zdroj: | Otology & Neurotology, 34, 5, pp. 838-844 ResearcherID Otology & neurotology 34(5), 838-844 (2013). doi:10.1097/MAO.0b013e318288646a Otology and neurotology Otology & Neurotology, 34, 838-844 |
| ISSN: | 1531-7129 |
| Popis: | Item does not contain fulltext OBJECTIVE: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated. STUDY DESIGN: Multicenter survey in 8 European centers. SUBJECTS: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study. RESULTS: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies. DISCUSSION: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects. |
| Databáze: | OpenAIRE |
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