Human Symbionts Use a Host-Like Pathway for Surface Fucosylation
| Autor: | Michael J. Coyne, Laurie E. Comstock, Martin M. Lee, Barbara Reinap |
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| Rok vydání: | 2005 |
| Předmět: |
Molecular Sequence Data
Mutant Guanosine Diphosphate Fucose Microbiology Bacteroides fragilis Feces Mice chemistry.chemical_compound Adenosine Triphosphate Bacterial Proteins Animals Humans Intestinal Mucosa Symbiosis Bacteroidaceae Bacterial Capsules Hydro-Lyases Fucosylation Glycoproteins chemistry.chemical_classification Multidisciplinary biology Host (biology) Molecular Mimicry biology.organism_classification Culture Media Intestines Phosphotransferases (Alcohol Group Acceptor) chemistry Genes Bacterial Mutation Guanosine Triphosphate Bacteroides Glycoprotein Gene Deletion Bacteria |
| Zdroj: | Science. 307:1778-1781 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1106469 |
| Popis: | The mammalian intestine harbors a beneficial microbiota numbering approximately 10 12 organisms per gram of colonic content. The host tolerates this tremendous bacterial load while maintaining the ability to efficiently respond to pathogenic organisms. In this study, we show that the Bacteroides use a mammalian-like pathway to decorate numerous surface capsular polysaccharides and glycoproteins with l -fucose, an abundant surface molecule of intestinal epithelial cells, resulting in the coordinated expression of this surface molecule by host and symbiont. A Bacteroides mutant deficient in the ability to cover its surface with l -fucose is defective in colonizing the mammalian intestine under competitive conditions. |
| Databáze: | OpenAIRE |
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