Altered plasma and brain disposition of isopropylidene shikimic acid liposome in rats and the brain protection in cerebral ischemia-reperfusion
| Autor: | Jiang Li, Jing Fu, Hui Kong, Xingbin Yin, Hui Zhang, Pei Yang, Longfei Lin, Jian Ni, Jingchen Tian, Changhai Qu |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Drug Compounding Ischemia Pharmaceutical Science Context (language use) Shikimic Acid Oxidative phosphorylation Pharmacology Brain Ischemia Rats Sprague-Dawley chemistry.chemical_compound Random Allocation Pharmacokinetics Drug Discovery medicine Distribution (pharmacology) Animals Tissue Distribution Neurons Liposome Drug Carriers Dose-Response Relationship Drug business.industry Organic Chemistry Brain Shikimic acid medicine.disease Rats Disease Models Animal Neuroprotective Agents chemistry Blood-Brain Barrier Pharmacodynamics Reperfusion Injury Injections Intravenous Liposomes business Half-Life |
| Zdroj: | Drug development and industrial pharmacy. 39(9) |
| ISSN: | 1520-5762 |
| Popis: | Cerebral ischemia-reperfusion (I/R) injury is a secondary injury caused by oxidative stresses and inflammatory responses after recovery from cerebral ischemia. Brain protective drugs were used to reduce the injury. In order to improve the distribution in brain and enhance the brain-protective efficacy, some pharmaceutical technologies were used to achieve brain targeting delivery.To investigate the physiological disposition of ISA liposome, and provide references for the further study about high-efficacy brain-protective preparations for I/R injury.Comparative studies were carried out. The pharmacodynamics in t-MCAO model rats were studied first, and then the pharmacokinetics and brain distribution of the two preparations were determined.At the same dose, the efficacy of ISA liposome was better (P0.05). The efficacy was dose dependent, with significant difference of 20 mg/kg (P0.01) and indistinctive difference of 10 mg/kg (P = 0.22), compared with vehicle-treated rats. The parameters, T(1/2β), MRT and AUC were different significantly between the two preparations. The enhancement of brain distribution for ISA in the liposome was obvious, with the maximum concentration 7.18 μg/g, while close to zero for the solution group.ISA liposome could increase the distribution in brain and enhance the efficacy significantly. The results revealed that the liposomal DDS was potential as a novel strategy for the treatment of cerebral I/R injury. In addition, further targeted modification, such as PEG-modified liposomes, which possess a long circulating property in the bloodstream, would further improve the targeting delivery to the brain and lead to more significant efficacy. |
| Databáze: | OpenAIRE |
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