Role of endoscopic ultrasonography in the diagnostic work-up of idiopathic acute pancreatitis (PICUS)
| Autor: | Adriaan C.I.T.L. Tan, Chantal V Hoge, Tessa E H Römkens, Annemieke Y. Thijssen, Niels G. Venneman, Stefan A W Bouwense, G. Willemien Erkelens, Jan-Werner Poley, Marc G. Besselink, Nora D L Hallensleben, Sjoerd D. Kuiken, Rina A Bijlsma, Menno A. Brink, Akin Inderson, Wouter L. Hazen, Hjalmar C. van Santvoort, Hendrik M. van Dullemen, Erwin J M van Geenen, Brechje C van Eijck, Marja A. Boermeester, Jeanin E van Hooft, Ben J.M. Witteman, Marie-Paule Anten, Devica S Umans, Lieke Hol, Lars E. Perk, Paul Fockens, Rutger Quispel, Marco J. Bruno, Annet M. C. J. Voorburg, Frank P. Vleggaar, Roy L.J. van Wanrooij, Hester C. Timmerhuis, Robert C. Verdonk, Wouter L. Curvers, Liesbeth M. Kager, Abha Bhalla |
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| Přispěvatelé: | MUMC+: MA Heelkunde (9), Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: FHML non-thematic output, Center for Liver, Digestive and Metabolic Diseases (CLDM), Gastroenterology & Hepatology, Gastroenterology and Hepatology, Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
etiology infected necrotizing pancreatitis Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0] Gastroenterology and Hepatology magnetic-resonance cholangiopancreatography hepatobiliary disease Endosonography Recurrent pancreatitis All institutes and research themes of the Radboud University Medical Center GALLSTONE PANCREATITIS medicine Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14] MANAGEMENT Humans Multicenter Studies as Topic EPIDEMIOLOGY Prospective Studies endoscopy Prospective cohort study EUS Netherlands First episode COMPLICATIONS ATLANTA CLASSIFICATION business.industry ultrasound Hepatobiliary disease General Medicine Guideline medicine.disease Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] Pancreatitis Acute Disease Emergency medicine Good clinical practice Quality of Life Acute pancreatitis Medicine business pancreatic disease |
| Zdroj: | BMJ Open, 10(8):035504. BMJ Publishing Group BMJ Open, Vol 10, Iss 8 (2020) BMJ Open, 10, 8 BMJ Open, 10(8). BMJ PUBLISHING GROUP BMJ Open, 10(8):e035504. BMJ PUBLISHING GROUP BMJ Open, 10(8):e035504. BMJ Publishing Group BMJ open, 10(8). BMJ Publishing Group BMJ Open BMJ Open, 10 |
| ISSN: | 2044-6055 |
| Popis: | IntroductionIdiopathic acute pancreatitis (IAP) remains a dilemma for physicians as it is uncertain whether patients with IAP may actually have an occult aetiology. It is unclear to what extent additional diagnostic modalities such as endoscopic ultrasonography (EUS) are warranted after a first episode of IAP in order to uncover this aetiology. Failure to timely determine treatable aetiologies delays appropriate treatment and might subsequently cause recurrence of acute pancreatitis. Therefore, the aim of the Pancreatitis of Idiopathic origin: Clinical added value of endoscopic UltraSonography (PICUS) Study is to determine the value of routine EUS in determining the aetiology of pancreatitis in patients with a first episode of IAP.Methods and analysisPICUS is designed as a multicentre prospective cohort study of 106 patients with a first episode of IAP after complete standard diagnostic work-up, in whom a diagnostic EUS will be performed. Standard diagnostic work-up will include a complete personal and family history, laboratory tests including serum alanine aminotransferase, calcium and triglyceride levels and imaging by transabdominal ultrasound, magnetic resonance imaging or magnetic resonance cholangiopancreaticography after clinical recovery from the acute pancreatitis episode. The primary outcome measure is detection of aetiology by EUS. Secondary outcome measures include pancreatitis recurrence rate, severity of recurrent pancreatitis, readmission, additional interventions, complications, length of hospital stay, quality of life, mortality and costs, during a follow-up period of 12 months.Ethics and disseminationPICUS is conducted according to the Declaration of Helsinki and Guideline for Good Clinical Practice. Five medical ethics review committees assessed PICUS (Medical Ethics Review Committee of Academic Medical Center, University Medical Center Utrecht, Radboud University Medical Center, Erasmus Medical Center and Maastricht University Medical Center). The results will be submitted for publication in an international peer-reviewed journal.Trial registration numberNetherlands Trial Registry (NL7066). Prospectively registered. |
| Databáze: | OpenAIRE |
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