2-Alkyloxazoles as potent and selective PI4KIIIβ inhibitors demonstrating inhibition of HCV replication

Autor:	Michael D. Connolly, Matthew J. LaMarche, Lawrence G. Hamann, Ayako Honda, Brigitte Wiedmann, Subramanian Karur, Shawn D. Britt, Markus Dobler, Rajeshri Ganesh Karki, Prakash Raman, Anup Patnaik, Samantha Sokup, Erin P. Keaney
Rok vydání:	2014
Předmět:	Clinical Biochemistry Pharmaceutical Science Hepacivirus Microbial Sensitivity Tests Class iii Virus Replication Antiviral Agents Biochemistry Virus Structure-Activity Relationship Drug Discovery Replication (statistics) Genotype Humans Replicon Beta (finance) Oxazoles Protein Kinase Inhibitors Molecular Biology Dose-Response Relationship Drug Molecular Structure Chemistry Organic Chemistry Virology Molecular biology In vitro Phosphotransferases (Alcohol Group Acceptor) Molecular Medicine
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 24:3714-3718
ISSN:	0960-894X
Popis:	Synthesis and SAR of 2-alkyloxazoles as class III phosphatidylinositol-4-kinase beta (PI4KIIIβ) inhibitors is described. These compounds demonstrate that inhibition of PI4KIIIβ leads to potent inhibition of HCV replication as observed in genotype (GT) 1a and 1b replicon and GT2a JFH1 virus assays in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd89a1f44474311f1155702c2f42685c https://doi.org/10.1016/j.bmcl.2014.07.015 Zobrazit plný text záznamu Full Text from ScienceDirect