Cushing's Syndrome Secondary to Olfactory Neuroblastoma
| Autor: | Bernd W. Scheithauer, Mark A. Arnesen, Susan Freeman |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Nasal cavity Pathology medicine.medical_specialty Nose Neoplasms Esthesioneuroblastoma Olfactory Adrenocorticotropic hormone Pathology and Forensic Medicine Esthesioneuroblastoma Structural Biology medicine Humans Cushing Syndrome biology Olfactory Neuroblastoma Remission Induction Chromogranin A medicine.disease Immunohistochemistry medicine.anatomical_structure Anterior cranial fossa Primitive neuroectodermal tumor biology.protein Synaptophysin Female Nasal Cavity |
| Zdroj: | Ultrastructural Pathology. 18:61-68 |
| ISSN: | 1521-0758 0191-3123 |
| Popis: | A case of olfactory neuroblastoma in a 36-year-old woman who presented with florid Cushing's syndrome is reported. A nasal polyp, which proved to be an olfactory neuroblastoma, was resected. The procedure was followed by complete remission from the endocrinologic abnormalities. Postoperatively, the patient was well for 5 years until recurrence of both Cushing's syndrome and the nasal polyp was noted. Following combined transnasal-transcranial resection of the tumor, which extended into the anterior cranial fossa, the patient again experienced complete remission of Cushing's syndrome. Immunohistochemistry showed the tumor to be positive for neuron-specific enolase, synaptophysin, chromogranin, adrenocorticotropic hormone, beta-endorphin, and S-100 protein. Electron microscopy revealed neuritic processes containing microtubules and neurosecretory granules. This is the first reported case of Cushing's syndrome secondary to olfactory neuroblastoma. |
| Databáze: | OpenAIRE |
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