A comparison of the pharmacodynamics of rocuronium and vecuronium during halothane anaesthesia
| Autor: | B. Marsh, M. G. Booth, E. N. Robertson, F. M. M. Bryden, W. L. M. Baird |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Time Factors Blood Pressure Heart Rate Heart rate Humans Medicine Androstanols Prospective Studies Rocuronium Adverse effect Neuromuscular Blockade Vecuronium Bromide business.industry Halothane anaesthesia Middle Aged Anesthesiology and Pain Medicine Single bolus Anesthesia Pharmacodynamics Female Halothane Anesthesia Inhalation business Muscle Contraction Neuromuscular Nondepolarizing Agents medicine.drug |
| Zdroj: | Anaesthesia. 47:832-834 |
| ISSN: | 1365-2044 0003-2409 |
| DOI: | 10.1111/j.1365-2044.1992.tb03139.x |
| Popis: | Summary Thirty healthy patients were randomised to receive either a single bolus dose of rocuronium 0.6mg.kg−1 or vecuronium 0.1 mg.kg−1 during halothane anaesthesia. Onset time, duration 25, duration 75 and train-of-four 70 were measured. The onset of neuromuscular blockade following rocuronium was more rapid than vecuronium (p = 0.0001). All other pharmacodynamic parameters were similar. During the first minute following injection of the neuromuscular blocking agent, the heart rate increased by 36% in the rocuronium group but remained stable in those patients who received vecuronium (p = 0.0008). No adverse effects were noted in either group. |
| Databáze: | OpenAIRE |
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