Cross-Sectional Examination of Homocysteine Levels with Sarcopenia and Its Components in Memory Clinic Outpatients
| Autor: | Masaaki Nagae, Kazuhisa Watanabe, Hiroyuki Umegaki, Hitoshi Komiya, Masafumi Kuzuya, Takashi Sakurai, Taiki Sugimoto, Fumie Kinoshita, Chi Hsien Huang, Chisato Fujisawa, Yosuke Yamada |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Sarcopenia medicine.medical_specialty Outpatient Clinics Hospital Homocysteine Logistic regression chemistry.chemical_compound Grip strength Internal medicine Outpatients medicine Humans Dementia Cognitive Dysfunction Risk factor Aged Aged 80 and over Hand Strength business.industry General Neuroscience Memory clinic Muscle weakness General Medicine medicine.disease Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies chemistry Female Geriatrics and Gerontology medicine.symptom business Biomarkers |
| Zdroj: | Journal of Alzheimer's Disease. 82:975-984 |
| ISSN: | 1875-8908 1387-2877 |
| Popis: | Background: Homocysteine is a common risk factor for cognitive impairment and sarcopenia. However, very few studies have shown an association between sarcopenia and serum homocysteine levels after adjustment for cognitive function. Objective: The purpose of this study was to investigate the relationship between homocysteine and sarcopenia in memory clinic patients. Methods: This cross-sectional study investigated outpatients in a memory clinic. We enrolled 1,774 participants (≥65 years old) with measured skeletal muscle mass index (SMI), hand grip strength (HGS), and homocysteine. All participants had undergone cognitive assessments and were diagnosed with dementia, mild cognitive impairment, or normal cognition. Patient characteristics were compared according to sarcopenia presence, SMI level, or HGS. Multivariate logistic regression analysis was performed to determine the association of homocysteine with sarcopenia, low SMI, or low HGS. Next, linear regression analysis was performed using HGS as a continuous variable. Results: Logistic regression analysis showed that low HGS was significantly associated with homocysteine levels (p = 0.002), but sarcopenia and low SMI were not. In linear regression analysis, HGS was negatively associated with homocysteine levels after adjustment for Mini-Mental State Examination score (β= –2.790, p |
| Databáze: | OpenAIRE |
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