Determinants of Cardiorespiratory Fitness Following Thoracic Radiotherapy in Lung or Breast Cancer Survivors
| Autor: | Salvatore Carbone, Ryan S. Garten, Adolfo G Mauro, Benjamin W. Van Tassell, Dinesh Kadariya, Medina de Chazal, Justin M. Canada, John D. Grizzard, Hayley Billingsley, Ronald K. Evans, Leo F. Buckley, Cory R. Trankle, William G Hundley, Antonio Abbate, Stefano Toldo, Ross Arena, Elisabeth Weiss, Eleonora Mezzaroma |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Lung Neoplasms medicine.drug_class Diastole Breast Neoplasms 030204 cardiovascular system & hematology Doppler echocardiography Article Pulmonary function testing Cohort Studies 03 medical and health sciences 0302 clinical medicine Breast cancer Oxygen Consumption Cancer Survivors Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans Radiation Injuries Aged medicine.diagnostic_test business.industry Cardiorespiratory fitness Heart Radiotherapy Dosage Middle Aged medicine.disease Peptide Fragments Cardiorespiratory Fitness 030220 oncology & carcinogenesis Cohort Cardiology Female Cardiology and Cardiovascular Medicine business Biomarkers Cohort study |
| Zdroj: | Am J Cardiol |
| ISSN: | 1879-1913 |
| Popis: | We measured peak oxygen consumption (VO(2)) in previous recipients of thoracic radiotherapy and assessed the determinants of cardiorespiratory fitness with an emphasis on cardiac and pulmonary function. Cancer survivors who have received thoracic radiotherapy with incidental cardiac involvement often experience impaired cardiorespiratory fitness, as measured by reduced peak VO(2), a marker of impaired cardiovascular reserve. We enrolled 25 subjects 1.8 (0.1 to 8.2) years following completion of thoracic radiotherapy with significant heart exposure (at least 10% of heart volume receiving at least 5 Gray). All subjects underwent cardiopulmonary exercise testing, Doppler echocardiography, and circulating biomarkers assessment. The cohort included 16 Caucasians (64%), 15 women (60%) with a median age of 63 (59 to 66) years. The peak VO(2) was 16.8 (13.5 to 21.9) ml·kg(−1)·min(−1) or moderately reduced at 62% (50% to 93%) of predicted. The mean cardiac radiation dose was 5.4 (3.7 to 14.7) Gray, and it significantly correlated inversely with peak VO(2) (R = −0.445, p = 0.02). Multivariate regression analysis revealed the diastolic functional reserve index and the N-terminal pro-brain natriuretic peptide (NTproBNP) serum levels were independent predictors of peak VO(2) ( = +0.813, p |
| Databáze: | OpenAIRE |
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