Behavior of A Cell Line Derived from A Mouse Submaxillary Adenocarcinoma during the Initial 480 Days in Vitro
| Autor: | Ritrovato R, Muller A, Giuliano Mg, Meo P, Bellocchi R, Botta I, Bellocci M, Castelli L, Giovanni Neri |
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| Rok vydání: | 1978 |
| Předmět: |
Cancer Research
medicine.medical_specialty Submandibular Gland Adenocarcinoma Oncogenicity Immunofluorescence Chromosomes Cell Line Inclusion Bodies Viral 030218 nuclear medicine & medical imaging Mice 03 medical and health sciences 0302 clinical medicine Antigens Neoplasm Internal medicine medicine Animals Cells Cultured medicine.diagnostic_test Chemistry Karyotype Neoplasms Experimental General Medicine Salivary Gland Neoplasms medicine.disease Molecular biology Submandibular gland In vitro Agglutination (biology) Endocrinology medicine.anatomical_structure Oncology Cell culture Karyotyping 030220 oncology & carcinogenesis Oncogenic Viruses |
| Zdroj: | Tumori Journal. 64:1-14 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.1177/030089167806400101 |
| Popis: | A cell line was established from a transplantable adenocarcinoma, containing viral particles of the A and B type, derived from a tumor appearing spontaneously in the submaxillary region of a male mouse of the C3H/He strain. This line, after 480 days in vitro, did not change the original epithelial-like morphology, the viral expression, the membrane immunofluorescence and the degree of agglutination by various plant lectins. After 208 days of culture, the presence of up to 3 pairs of metacentric chromosomes appeared in about 55% of the cells. However, this change in the chromosomal pattern was not sufficient, at least within the limits of our observation, to modify significantly the other parameters investigated, with the possible exception of the oncogenicity, which showed a modest decrease after 296 days of culture. |
| Databáze: | OpenAIRE |
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