Downregulation of AGR 2, p21, and cyclin D and alterations in p53 function were associated with tumor progression and chemotherapy resistance in epithelial ovarian carcinoma
| Autor: | Nayra Soares do Amaral, Rafael Malagoli Rocha, Mateus Camargo Barros-Filho, Felipe Ilelis de Barros Silva, Natália Cruz e Melo, Fernando Augusto Soares, Glauco Baiocchi Neto, Mariana Rezende Alves, Louise De Brot Andrade |
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| Rok vydání: | 2018 |
| Předmět: |
epithelial ovarian cancer
0301 basic medicine Cancer Research Serous carcinoma Cyclin D AGR2 03 medical and health sciences 0302 clinical medicine Cyclin D1 Medicine Radiology Nuclear Medicine and imaging RC254-282 Original Research Cancer Biology biology business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell cycle medicine.disease 030104 developmental biology Oncology Tumor progression 030220 oncology & carcinogenesis Cancer research biology.protein Immunohistochemistry Biomarker (medicine) cell cycle prognosis business IHC |
| Zdroj: | Cancer Medicine, Vol 7, Iss 7, Pp 3188-3199 (2018) Cancer Medicine |
| ISSN: | 2045-7634 |
| DOI: | 10.1002/cam4.1530 |
| Popis: | Anterior gradient 2 protein belongs to a family of chaperone‐like proteins, namely protein disulfide isomerase. Generally, AGR2 is highly expressed in mucus‐secreting cells and endocrine organs, and in this study, we aimed to evaluate AGR2 and cell cycle molecules in epithelial ovarian cancer and its implications on prognosis. One hundred seventy‐five patient's samples that were diagnosed with primary epithelial ovarian carcinoma were selected. All the patients were treated with platinum‐taxane standard chemotherapy after surgery and CA125 serum levels were routinely determined. Four‐micrometer‐thick sections were processed by immunohistochemistry using an automated immunostainer, Ventana BenchMark AutoStainer with AGR2, cyclin D1, p21WAF1, and p53. Forty‐nine of 167 cases (29.3%) showed strong to moderate cytoplasmic marking of AGR2, and 118 (70.7%) had weak to negative expression. The absence of the AGR2 protein was observed in high‐grade serous carcinoma (P |
| Databáze: | OpenAIRE |
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