| Autor: |
Peiru Wang, Bo Wang, Linglin Zhang, Xiaojing Liu, Lei Shi, Xiaojing Kang, Xia Lei, Kun Chen, Zhou Chen, Chengxin Li, Chunlei Zhang, Ping Tu, Meng Pan, Qiang Ju, Xiaoyong Man, Yan Lu, Nan Yu, Yuzhen Li, Huilan Zhu, Ruzhi Zhang, Juan Su, Shiqin Tao, Jianjun Qiao, Qiri Mu, Weihui Zeng, Zhiming Li, Ying Gao, Heng Gu, Xiuli Wang |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Photodiagnosis and photodynamic therapy. |
| ISSN: |
1873-1597 |
| Popis: |
A variety of evidence suggest that 5-Aminolevulinic acid-based photodynamic therapy (ALA-PDT) is clinically effective in management of acne vulgaris. Several clinical guidelines for acne recommend PDT as an alternative treatment modality for severe acne. However, there is a lack of detailed clinical guideline for PDT in acne treatment. To propose up-to-date, evidence-based and practical recommendations on application of ALA-PDT for acne vulgaris, dermatologists and PDT experts from the Photodynamic Therapy Research Center of the CMA and Photodynamic Therapy Rehabilitation Training Center of CARD achieved consensus and guidelines based on careful evaluation of published literature, expert opinions and experience. ALA-PDT plays a therapeutic role in all four major pathogenesis of acne, and is suitable for moderate to severe acne and scar-prone acne, especially for patients who cannot tolerate or refused systemic antibiotics and isotretinoin. The efficacy and adverse reactions of ALA-PDT are closely related to therapeutic parameters including ALA concentration, incubation time, light source and dosage. Proper pretreatment helps to improve transdermal absorption of ALA and enhances its efficacy. We reviewed and proposed recommended protocols for four PDT procedures including conventional PDT (C-PDT), modified painless PDT (M-PDT), intense pulsed light PDT (IPL-PDT) and daylight PDT (DL-PDT). M-PDT with lower ALA concentration (3-5%), shorter incubation time (30 min), and lower dose but prolonged illumination (630nm, 40-60 mW/cm |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect