Monosialoganglioside GM1 in Experimental Models of Stroke

Autor:	M. C. Comelli, R. Zanoni, Diego Guidolin, H. Manev, M. S. Seren, A. Lazzaro, R. Canella
Rok vydání:	1994
Předmět:	Glutamate receptor Excitotoxicity Brain damage medicine.disease medicine.disease_cause Pathogenesis chemistry.chemical_compound chemistry Interstitial fluid medicine medicine.symptom Neurotransmitter Cell damage Neuroscience Ionotropic effect
Zdroj:	Cerebral Ischemia and Basic Mechanisms ISBN: 9783642781537
DOI:	10.1007/978-3-642-78151-3_13
Popis:	It is now well established that the neurotransmitter glutamate plays a prominentrole in the pathogenesis of hypoxic-ischemic brain damage [1, 2] High levels of glutamate accumulate in the interstitial fluid during an ischemic/traumatic episode [3] and, through the activation of ionotropic glutamate receptors, initiate a cascade of cellular events which ultimately lead to irreversible cell damage. These cellular events contributing to excitotoxicity appear to be triggered largely by destabilization of calcium homeostasis [4].
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd853a03542dfb7c85429a480810dfef https://doi.org/10.1007/978-3-642-78151-3_13 Zobrazit plný text záznamu