Propylene glycol monomethyl ether (PGME): inhalation toxicity and carcinogenicity in Fischer 344 rats and B6C3F1 mice
| Autor: | Jerry F. Hardisty, Frank S. Cieszlak, Richard A. Corley, W.T. Stott, J. W. Crissman, Pamela J. Spencer, A.M. Schumann |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Toxicology 030226 pharmacology & pharmacy Mixed Function Oxygenases S Phase 0403 veterinary science Mice 0302 clinical medicine Neoplasms Chronic toxicity Kidney Inhalation Adrenal gland 04 agricultural and veterinary sciences Kidney Neoplasms Dose–response relationship medicine.anatomical_structure Biochemistry Liver Enzyme Induction Toxicity Female Adenoma DNA Replication medicine.medical_specialty 040301 veterinary sciences Carcinogenicity Tests Longevity Mice Inbred Strains Pathology and Forensic Medicine Nephropathy 03 medical and health sciences Internal medicine Administration Inhalation Alpha-Globulins medicine Animals Molecular Biology Carcinogen Dose-Response Relationship Drug business.industry Cell Biology DNA medicine.disease Rats Inbred F344 Rats Endocrinology Propylene Glycols Carcinogens business |
| Zdroj: | Toxicologic pathology. 30(5) |
| ISSN: | 0192-6233 |
| Popis: | A series of inhalation studies with propylene glycol monomethyl ether (PGME) vapor were undertaken to characterize its subchronic toxicity in mice and chronic toxicity/oncogenicity in rats and mice. Groups of male and female Fischer 344 rats and B6C3F1 mice were exposed to 0,300, 1,000, or 3,000 ppm vapor from 1 week to 2 years. Primary treatment-related effects included: initial sedation of animals exposed to 3,000 ppm and its subsequent resolution correlating with induction of hepatic mixed function oxidase activity and S-phase DNA synthesis; elevated mortality in high-exposure male rats and mice (chronic study); elevated deposition of alpha2U-globulin ( α2U-G) and associated nephropathy and S-phase DNA synthesis in male rat kidneys; accelerated atrophy of the adrenal gland X-zone infemale mice (subchronic study only); and increased occurrence and/or severity of eosinophilic foci of altered hepatocytes in male rats. No toxicologically relevant statistically significant increases in neoplasia occurred in either species. A numerical increase in the incidence of kidney adenomas occurred in intermediate-exposure male rats; however, the association with α2U-G nephropathy, a male rat specific effect, indicated a lack of relevance for human risk assessment. |
| Databáze: | OpenAIRE |
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