Autoimmune thyroiditis in a child with steroid-dependent nephrotic syndrome
| Autor: | Meri Angjeleska, Nadica Ristoska-Bojkovska, Velibor Tasic, Gordana Petrusevska, Zoran Gucev |
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| Rok vydání: | 2008 |
| Předmět: |
endocrine system
Goiter endocrine system diseases Nephrosis Thyroid Gland Thyroiditis Drug Administration Schedule Autoimmune thyroiditis Adjuvants Immunologic Recurrence medicine Humans Adverse effect Child Autoantibodies Dose-Response Relationship Drug business.industry Nephrosis Lipoid Thyroid Thyroiditis Autoimmune Levamisole medicine.disease medicine.anatomical_structure Child Preschool Pediatrics Perinatology and Child Health Immunology Prednisone Drug Therapy Combination Female business Nephrotic syndrome Immunosuppressive Agents medicine.drug Follow-Up Studies |
| Zdroj: | European journal of pediatrics. 168(2) |
| ISSN: | 1432-1076 |
| Popis: | Autoimmune thyroiditis is rarely described in association with nephrotic syndrome. Herein we report a girl who developed autoimmune thyroiditis insidiously during the course of minimal change nephrotic syndrome. She was streroid-sensitive, but developed severe steroid dependency and did not respond to cyclophosphamide therapy. She went into stable remission with levamisole. Five months after introduction of levamisole a mild goiter was found on systematic examination at school. The diagnosis of autoimmune thyroiditis was established with typical ultrasound appearance of the thyroid gland along with significant titers of antithyroid antibodies. It is very unlikely that levamisole was responsible for thyroiditis because experimental animal administration of high doses of levamisole inhibited lymphocyte infiltration of the thyroid. Since levamisole has had a beneficial effect on the nephrotic syndrome in our patient we decided to continue the treatment. She has been receiving levamisole for 3 years, and no adverse effects have been observed during the treatment period. |
| Databáze: | OpenAIRE |
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