New phloroglucinol derivatives with protein tyrosine phosphatase 1B (PTP1B) inhibitory activities from Syzygium austroyunnanense
| Autor: | Feng Li, Yan Zhao, Li Wang, Jin-Ping Liu, Sheng-Xiong Huang, Meng-Jia Li, Yong Zhao, Yi-Kao Hu, Wen Xu, Shao-Hua Xu |
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| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Folk medicine Protein Tyrosine Phosphatase Non-Receptor Type 1 China biology Molecular Structure 010405 organic chemistry Electrospray ionization Syzygium Phloroglucinol Phytochemicals General Medicine Inhibitory postsynaptic potential biology.organism_classification 01 natural sciences Protein Tyrosine Phosphatase 1B 0104 chemical sciences Plant Leaves 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Biochemistry chemistry Drug Discovery |
| Zdroj: | Fitoterapia. 131 |
| ISSN: | 1873-6971 |
| Popis: | Five new phloroglucinol derivatives (1–5) together with one known analogue (6) were isolated from the leaves of Syzygium austroyunnanense which is an edible folk medicine used for the treatment of diabetes. The new structures were elucidated as austroyunones A − E (1–5) by means of the extensive spectroscopic analyses including high-resolution electrospray ionization mass spectrometry (HRESIMS) and 1D and 2D nuclear magnetic resonance (NMR). Compounds 4–6 showed obvious protein tyrosine phosphatase 1B (PTP1B) inhibitory activity. This discovery of new phloroglucinols and their bioactivities provided a scientific basis for the application of S. austroyunnanense as an edible and medicinal plant. |
| Databáze: | OpenAIRE |
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