Adult-onset Still's disease and the role of dermatological manifestations: A case report and literature review
| Autor: | Carmen Manciuc, Cristina Lăcătuşu, Andrei Vâță, Anca Cardoneanu, Ionela Adriana Vlăduțu, Alexandra Burlui, Elena Rezuș |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty Systemic disease Arthritis Disease rash 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) medicine Leukocytosis fever business.industry ferritin autoimmunity General Medicine Articles medicine.disease Dermatology Rash Neutrophilia 030104 developmental biology Infectious disease (medical specialty) inflammation 030220 oncology & carcinogenesis Etiology medicine.symptom business |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-0981 |
| Popis: | Adult-onset Still's disease (AOSD) is a rare inflammatory systemic disease with unknown etiology, characterized by spiking fever, evanescent rash, arthralgia and arthritis, leukocytosis and possible multi-organ involvement. Based on a case report of a 19-year-old man who was admitted to hospital for an influenza-like syndrome associated with a transient and recurrent pale-red disseminated non-specific rash, we performed a PubMed database search for cases and reviews of Adult's Onset Still's Disease published in English in the last 5 years. Due to its heterogeneous clinical manifestations, of which skin rash is an important sign, and the lack of a specific laboratory test, the diagnosis requires the exclusion of a wide range of mimicking disorders and the use of specific scoring systems. The high ferritin levels, major leukocytosis with neutrophilia, absence of typical antibodies for other systemic autoimmune diseases and other markers of infectious disease were the milestones that led to the positive diagnosis. The first line of treatment remains corticosteroid therapy in association with disease-modifying anti-rheumatic drugs. |
| Databáze: | OpenAIRE |
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