Future of oncologic photodynamic therapy
| Autor: | Ron R. Allison, Claudio Sibata, Vanderlei Salvador Bagnato |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
medicine.medical_specialty medicine.medical_treatment Photodynamic therapy Deep tissue Neoplasms Humans Medicine Photosensitizer Medical physics Light activation NEOPLASIAS (TRATAMENTO) Photosensitizing Agents business.industry Oxygen metabolism Aminolevulinic Acid General Medicine Photosensitizing Agent eye diseases Oxygen Clinical trial Mesoporphyrins Photochemotherapy Oncology Nanoparticles Dihematoporphyrin Ether business Forecasting |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1744-8301 1479-6694 |
| DOI: | 10.2217/fon.10.51 |
| Popis: | Photodynamic therapy (PDT) is a tumor-ablative and function-sparing oncologic intervention. The relative simplicity of photosensitizer application followed by light activation resulting in the cytotoxic and vasculartoxic photodynamic reaction has allowed PDT to reach a worldwide audience. With several commercially available photosensitizing agents now on the market, numerous well designed clinical trials have demonstrated the efficacy of PDT on various cutaneous and deep tissue tumors. However, current photosensitizers and light sources still have a number of limitations. Future PDT will build on those findings to allow development and refinement of more optimal therapeutic agents and illumination devices. This article reviews the current state of the art and limitations of PDT, and highlight the progress being made towards the future of oncologic PDT. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|