Delayed role of tumor necrosis factor- alpha in overcoming the effects of pertussis toxin
| Autor: | Daniel N. Wolfe, Paul B. Mann, Anne M. Buboltz, Eric T. Harvill |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
CD4-Positive T-Lymphocytes
Bordetella pertussis Neutrophils Whooping Cough medicine.medical_treatment Virulence Alpha (ethology) Inflammation Biology Pertussis toxin Microbiology Mice medicine Immunology and Allergy Animals Whooping cough Mice Knockout Tumor Necrosis Factor-alpha Airway Resistance medicine.disease biology.organism_classification Disease Models Animal Infectious Diseases Cytokine Pertussis Toxin Immunology Tumor necrosis factor alpha medicine.symptom |
| Zdroj: | The Journal of infectious diseases. 196(8) |
| ISSN: | 0022-1899 |
| Popis: | Bordetella pertussis causes whooping cough, an endemic respiratory disease that is increasing in prevalence despite vaccination efforts. Although host immunity is modulated by virulence factors of this pathogen, it is unclear what host factors are required to overcome their effects. Here, we investigate an apparent relationship between the effects of pertussis toxin and tumor necrosis factor (TNF)- alpha . B. pertussis grew efficiently and caused moderate pathology in wild-type mice, whereas TNF- alpha (-/-) mice had higher numbers of bacteria and leukocytes in lungs, experienced more airway resistance, and died of the infection. Interestingly, an isogenic B. pertussis strain lacking pertussis toxin did not induce these effects in TNF- alpha (-/-) mice and behaved similarly in wild-type and TNF- alpha -deficient hosts. Together, these results indicate that TNF- alpha is essential for the host to overcome the effects of pertussis toxin, allowing both control of B. pertussis numbers and regulation of the inflammation induced by infection. |
| Databáze: | OpenAIRE |
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