Type 2 Diabetes Mellitus and Alzheimer's Disease: A Review of the Potential Links
Autor: | Shirin Yaghoobpoor, Sina Namazi, Amirreza Pouladi, Niloofar Deravi, Zahra Arabpour, Mohammad Mehdi Mousavi Nasab, Samaneh Toutounchian, Majid Pakdin, Mohadeseh Poudineh, Sahar Afsahi |
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Rok vydání: | 2021 |
Předmět: |
Endocrinology
Diabetes and Metabolism medicine.medical_treatment Inflammation Disease Bioinformatics medicine.disease_cause Endocrinology Alzheimer Disease Diabetes mellitus medicine Animals Humans Insulin Amyloid beta-Peptides biology business.industry Type 2 Diabetes Mellitus Brain medicine.disease Insulin receptor Diabetes Mellitus Type 2 biology.protein Alzheimer's disease medicine.symptom business Oxidative stress |
Zdroj: | Current diabetes reviews. 18(8) |
ISSN: | 1875-6417 |
Popis: | Diabetes mellitus and Alzheimer’s disease are considered the most prevalent diseases in older ages worldwide. The main pathology of Alzheimer’s disease is highly related with accumulation of misfolded proteins that lead to neuronal dysfunction in the brain. On the other hand, diabetes mellitus is associated with alteration of insulin signaling, which could cause the reduction of glucose uptake, metabolic prohibition of energy consuming cells, as well as suppression of glucose to fat conversion in the liver. In spite of having seemingly different pathological features, both diseases share common underlying biological mechanisms. Besides, the epidemiological and environmental links between these two diseases should not be overlooked. In this study, we aim to review shared pathological mechanisms of Alzheimer’s disease and diabetes mellitus, including impaired glucose metabolism, increased Amyloid-Beta (Aβ) production, impaired lipid metabolism, mitochondrial dysfunction, increased inflammation and elevated oxidative stress. Furthermore, we discuss epidemiological association between these two diseases and also review animal investigations, which have evaluated the potential links between the two diseases. |
Databáze: | OpenAIRE |
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