Impact of activity-based recovery training and desmopressin on spinal cord injury-induced polyuria in Wistar rats
| Autor: | Charles H, Hubscher, Jason H, Gumbel, James E, Armstrong, Lynnette R, Montgomery |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | The Journal of Spinal Cord Medicine. :1-7 |
| ISSN: | 2045-7723 1079-0268 |
| DOI: | 10.1080/10790268.2022.2069538 |
| Popis: | Activity-based recovery training (ABRT) reverses spinal cord injury (SCI) induced polyuria and alterations of biomarkers involved with fluid balance, including expression levels of kidney vasopressin 2 receptors. However, void volumes do not return to pre-injury baseline levels, indicating a combinatorial approach may be necessary.In the current study, acute effects of a pharmacological intervention versus placebo were examined in male rats that had received 70 daily ABRT sessions. The treatment, desmopressin (DDAVP - synthetic analogue of arginine vasopressin), an antidiuretic therapy used for the management of bedwetting in children and central diabetes insipidus, has previously shown some promise in a few limited cohorts of SCI individuals having nocturnal polyuria.A total of 70 sessions of ABRT over a 10-week timeframe again reduced the overproduction of urine, but not completely to pre-SCI baseline levels. DDAVP treatment maintained but did not further reduce the level of urine output in the ABRT group without continuous exercise, demonstrating either intervention/treatment alone is effective, despite no additive effect. Although intake did not change from pre-injury levels despite polyuria, DDAVP treatment also reduced drink volume.Further studies are needed as the mechanisms underlying changes in fluid and solute balance are likely multi-factorial involving a complex interaction between the neural (both central and peripheral) control of systems mediating thirst, urinary output, and cardiovascular regulation. |
| Databáze: | OpenAIRE |
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