The DNA sequence, annotation and analysis of human chromosome 3
| Autor: | Zhengdong D. Zhang, Jun Wang, Zhu Chen, Will Gillett, George M. Weinstock, Guoping Zhao, LaRonda Jackson, Christopher K. Raymond, Manuel L. Gonzalez-Garay, Yang Zhou, Judith Hernandez, Boqin Qiang, James B. Clendenning, Zhijian J. Chen, Shannon Dugan-Rocha, Andrew R. Jackson, Zhijian Yao, Yan Shen, R. Alan Harris, Ziad Khan, Margaret Morgan, Wei Dong, Sharon Wei, Dawn Garcia, Aleksandar Milosavljevic, Maynard V. Olson, Ruben Rodriguez, Kerstin P. Clerc-Blankenburg, Ryan J. Lozado, Ralf Sudbrak, Jun Gu, Jing Kun Zhang, Heather R. Draper, Mary J. Brown, Channakhone Saenphimmachak, M. Ali Ansari-Lari, Songnian Hu, Preethi H. Gunaratne, Donna M. Muzny, Shiran Pasternak, Xing Zhi Song, Oliver Delgado, Bailin Hao, Lesette Perez, Charles Q. Adams, Michael L. Metzker, Anne Hodgson, Daniel Verduzco, Bao Viet Nguyen, Susan H. Kelly, Xin He, Jing Wang, Runsheng Chen, Karen A. Phelps, Rajinder Kaul, Guan Chen, Wei Huang, Huyen Dinh, Lenee Waldron, Paul Havlak, George Miner, Qiaoyan Wang, Ye Yuan, Rachel Gill, Anthony Palmeiri, Mathew W. Wright, Kim C. Worley, Michael Kube, Jing Liu, Clay Davis, Christian J. Buhay, Zhangwan Li, Jun Yu, Alicia Hawes, Jing Lu, Steffen Hennig, David L. Nelson, Rui Chen, Leni S. Jacob, Huanming Yang, Bin Liu, Steven E. Scherer, Christie Kovar-Smith, Jian Wang, Manjula Maheshwari, Gabrielle A. Williams, Paul E. Tabor, David A. Wheeler, Hans Lehrach, Graham R. Scott, Farah J.H. Plopper, Erica Sodergren, Wen Liu, Mulu Ayele, Richard Reinhardt, Richard A. Gibbs, Eric Haugen, Lora Lewis, Hua Shen, Gang Fu, Jianling Zhou, Xiuqing Zhang, Stephen Ernst, Geoffrey Okwuonu, Susan L. Naylor, Jennifer Hume, Ruth Levy, Andrew Cree, Yan Ding, David Steffen, Lynne V. Nazareth, Jireh Santibanez, Sandhya Subramanian, Gane Ka-Shu Wong |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Inversion
Chromosome Genome evolution DNA Complementary Pan troglodytes Molecular Sequence Data Biology Synteny Genome Evolution Molecular Chimpanzee genome project Contig Mapping Chromosome 19 Human Genome Project Animals Humans Expressed Sequence Tags Genetics Multidisciplinary Base Sequence Chromosome Breakage Sequence Analysis DNA Genome project Macaca mulatta Chromosome Inversion CpG Islands Human genome Chromosomes Human Pair 3 Chromosome 21 Reference genome |
| Zdroj: | Muzny, D M, Scherer, S E, Kaul, R, Wang, J, Yu, J, Sudbrak, R, Buhay, C J, Chen, R, Cree, A, Ding, Y, Dugan-Rocha, S, Gill, R, Gunaratne, P, Harris, R A, Hawes, A C, Hernandez, J, Hodgson, A V, Hume, J, Jackson, A, Khan, Z M, Kovar-Smith, C, Lewis, L R, Lozado, R J, Metzker, M L, Milosavljevic, A, Miner, G R, Morgan, M B, Nazareth, L V, Scott, G, Sodergren, E, Song, X-Z, Steffen, D, Wei, S, Wheeler, D A, Wright, M W, Worley, K C, Yuan, Y, Zhang, Z, Adams, C Q, Ansari-Lari, M A, Ayele, M, Brown, M J, Chen, G, Chen, Z, Clendenning, J, Clerc-Blankenburg, K P, Chen, R, Chen, Z, Davis, C, Delgado, O, Dinh, H H, Dong, W, Draper, H, Ernst, S, Fu, G, Gonzalez-Garay, M L, Garcia, D K, Gillett, W, Gu, J, Hao, B, Haugen, E, Havlak, P, He, X, Hennig, S, Hu, S, Huang, W, Jackson, L R, Jacob, L S, Kelly, S H, Kube, M, Levy, R, Li, Z, Liu, B, Liu, J, Liu, W, Lu, J, Maheshwari, M, Nguyen, B-V, Okwuonu, G O, Palmeiri, A, Pasternak, S, Perez, L M, Phelps, K A, Plopper, F J H, Qiang, B, Raymond, C, Rodriguez, R, Saenphimmachak, C, Santibanez, J, Shen, H, Shen, Y, Subramanian, S, Tabor, P E, Verduzco, D, Waldron, L, Wang, J, Wang, J, Wang, Q, Williams, G A, Wong, G K-S, Yao, Z, Zhang, J, Zhang, X, Zhao, G, Zhou, J, Zhou, Y, Nelson, D, Lehrach, H, Reinhardt, R, Naylor, S L, Yang, H, Olson, M, Weinstock, G & Gibbs, R A 2006, ' The DNA sequence, annotation and analysis of human chromosome 3 ', Nature, vol. 440, no. 7088, pp. 1194-1198 . https://doi.org/10.1038/nature04728 |
| ISSN: | 1476-4687 0028-0836 |
| Popis: | Udgivelsesdato: 2006-Apr-27 After the completion of a draft human genome sequence, the International Human Genome Sequencing Consortium has proceeded to finish and annotate each of the 24 chromosomes comprising the human genome. Here we describe the sequencing and analysis of human chromosome 3, one of the largest human chromosomes. Chromosome 3 comprises just four contigs, one of which currently represents the longest unbroken stretch of finished DNA sequence known so far. The chromosome is remarkable in having the lowest rate of segmental duplication in the genome. It also includes a chemokine receptor gene cluster as well as numerous loci involved in multiple human cancers such as the gene encoding FHIT, which contains the most common constitutive fragile site in the genome, FRA3B. Using genomic sequence from chimpanzee and rhesus macaque, we were able to characterize the breakpoints defining a large pericentric inversion that occurred some time after the split of Homininae from Ponginae, and propose an evolutionary history of the inversion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|